The present survey deals with an evaluation of the nonrenal and nonskeletal effects of excess PTH in uremia, taking into consideration the presently available information on the organ-specific expression of the classical and novel PTH receptors, and of the expression and function of PTHrP....
L. (2009). Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. Journal of bone and mineral research, 24(3), 372-384. 2. Marcus, J. N., & Brandi, M. L. (2009). Primary hyperparathyroidism: ...
Biochemical cure/control of acromegaly results in a reduction in PTH target-organ sensitivity (as indicated by a significant increase in PTH and decrease in NcAMP and ACa concentrations), and may lead to the previously reported reduction in bone turnover. PTH target-organ sensitivity and phospho...
The heart contains the mRNA for this receptor and it is a target organ for PTH action. We examined whether the message of the PTH-PTHrP receptor is down-regulated in the heart of CRF animals and evaluated the role of [Ca2+]i in this process. The expression of the mRNA of the PTH-PT...
The heart is a major target organ for thyroid hormone action, and marked changes occur in cardiac function in patients with hypo- or hyperthyroidism. T-3-i... A Mario - 《Endocrinology》 被引量: 11发表: 2005年 PD-1 blockade in Hodgkin's lymphoma: learning new tricks from an old teacher...
I. et al. Mineralizing surface is the main target of mechanical stimulation independent of age: 3D dynamic in vivo morphometry. Bone 66, 15–25 (2014). Article PubMed Google Scholar van ‘t Hof, R. J. & Dall’Ara, E. Analysis of bone architecture in rodents using micro-computed ...
Z Kmieć,I Sokołowska - 《Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego》 被引量: 42发表: 2007年 Therapeutic targeting of a stem cell niche These data provide evidence that the niche may be an attractive target for drug-based stem cell therapeutics.doi:10.1038/nbt1281Greg...
We next examined whether PCO371 induces PTH-like bone- resorbing activity in organ cultures with fetal rat long bones. PCO371 at 1 mmol l À 1 or more had the ability to stimulate 45Ca release from prelabeled bones as did hPTH(1–34) (Fig. 3). Mechanism of selectivity for PTHR1 ...
Canonical PDZ–ligand interactions occur when a short length of three to four residues (β-strand) at the carboxy terminus of the target peptide occupies the PDZ-binding site. Therefore, WT RGS14ct-9 peptide or mutated variants were modeled as linear peptides bound to PDZ2. MD trajectories ...
The length of the treatment (30 days vs. hours) and the model used (mice vs. bone organ cultures) may account for the differences between these two groups of studies. 3.2.3. The Downstream Regulatory Networks of PTH That Are Anabolic in T Cells Earlier research has indicated that T ...