It is necessary to monitor the developing biology of the target, not only in the target tissue. The function may not be the same in all tissues. • Tissue distribution studies add tissues or species continuously. It is probably rare for a protein to be expressed in a tissue for no reaso...
Pseudohypoparathyroidism (PsHP) is the generic term for a clinical disorder characterized by target tissue resistance to the action(s) of parathyroid hormone (PTH). The biochemical expressions of PTH resistance include hypocalcemia, hyperphosphatemia, and increased circulating levels of PTH appropriate...
Suspicious tissue can be accessed with fine-needle aspiration (FNA) using US guidance, and the aspirate can be sent for PTH assay [57]. Highly selective venous catheterization can be performed in those cases where imaging fails to localize a gland and is limited in the information that it ...
Eltrombopag for the treatment of refractory thrombocytopenia associated with connective tissue disease Sci. Rep., 11 (2021), p. 5459 10.1038/s41598-021-84493-2 CrossrefGoogle Scholar 145. Lee J. H., Choi N., Kim S., Jin M. S., Shen H., Kim Y. C. Eltrombopag as an Allosteric Inhi...
Here we summarize emerging therapies that target or act via Wnt signaling pathways, in terms of small molecule antagonists or agonists, herbs, enzymes, and tissue engineering and so on. Cartilage Small-molecule inhibitors First and most importantly, SM04690 was shown to elicit protective effects on...
4.6. Whole Genome Sequencing Genomic DNA was extracted from the tail tissue of a heterozygous F1 mouse with white spot and subjected to paired-end 2× 150 bp Illumina sequencing, generating approximately 400 million reads. Raw reads were analyzed by using FastQC software, to ...
Ann NY Acad Sci 1070:337–341 Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (1992) Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 8:811–819 Itoh N, Obata K, Yanaihara N, Okamoto H (1983) Human preprovasoactive ...
Cell isolation. To isolate murine bone marrow neutrophils, the femur and the tibia from both hind legs were removed and freed of soft tissue attachments, and the extreme distal tip of each extremity cut off. HBSS contain- ing 15 mM EDTA and 30 mM HEPES was forced through the bone...
Intestinal permeation enhancers for oral peptide delivery Adv. Drug Deliv. Rev., 106 (2016), pp. 277-319, 10.1016/j.addr.2016.06.005 View PDFView articleGoogle Scholar [7] E.M. Danielsen, G.H. Hansen Probing paracellular - versus transcellular tissue barrier permeability using a gut mucosal...
added to wells for 30 minutes, RT. Substrate was removed and All samples were run in duplicates. Plaque forming units per g lung tissue were calculated accordingly: dilution factor × average number of plaque/well × 20 wells/ml = PFU/mg Detection level was calculated to be 1000 PFU/mg...