The classical target organs for parathyroid hormone (PTH) are the bone and kidneys. In uremia, however, numerous studies have shown that PTH may also affect the function of a number of nonclassical organs and tissues besides the bone and kidney, including the brain, heart, smooth muscles, ...
甲状旁腺激素(parathyroid hormone,PTH)是一种由甲状旁腺细胞分泌的激素,它在维持钙磷代谢平衡中具有重要作用。PTH通过调节骨骼释放钙和磷以及肾脏重吸收钙和排泄磷来维持血钙水平的稳定。PTH的正常范围对于评估钙磷代谢的平衡至关重要。 正常PTH水平的定义是指其浓度在特定范围内,此范围因不同实验室而异,因此需要参...
Learning new tricks from an old dog: the processing of the intracellular precursor of the luteinizing hormone receptor (LHR) into the mature cell-surface L... The heart is a major target organ for thyroid hormone action, and marked changes occur in cardiac function in patients with hypo- or...
Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it bind... GH actions are dependent on receptor dimerization. The GH receptor antagonist, B2036-PEG, has been developed for treating acromegaly. B203...
to the action of a variety of hormones, a rise in [Ca2+]i and decrease in the amount of mRNA of one hormone receptor, the PTH-PTHrP receptor. W... SG Massry,M Klin,Z Ni,... - 《Kidney International》 被引量: 41发表: 1995年 慢性肾功能衰竭甲状旁腺激素和甲状旁腺激素相关蛋白的变化...
Recombinant parathyroid hormone [1–34] (PTH(1–34)) is the basis of two FDA-approved bone anabolics prescribed for treatment of OP and associated bone deficits. It is effective for increasing bone mass and strength6,7, which clinically corresponded with a 65% and 56% reduction in vertebral...
Tohru Esaki1, Kotaro Ogawa1, Taiji Miyake1, Shinichi Arai1, Masaru Shimizu1, Hidetomo Kitamura1, Haruhiko Sato1 & Yoshiki Kawabe1 Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled rece...
摘要: Compositions comprising PTH-rP peptides, combinations thereof, and multiepitope PTH-rP peptides, vectors for their delivery to antigen presenting cells, as well as methods are provided which are useful in the immunotherapy of parathyroid hormone related peptide expressing malignancies....
The goal of the work here was to determine the effect of WT RGS14 and the identified PDZ ligand mutations on basal and hormone-regulated Pi transport and the role of RGS14 interactions with NHERF1 in this process. The described studies use a combination of native RGS14 expression in donor...
Sympathetic tone acts via beta2 adrenergic receptors in bone and regulates the mass of bone which is the target organ of parathyroid hormone (PTH). However, whether beta2 adrenergic receptor is regulated by PTH in bone cells is not known. We therefore investigated the effects of PTH on beta2...