The major target organs for parathyroid hormone (PTH) are the bone and kidney. PTH regulates or influences metabolism of calcium and phosphate in these tissues and its action is presumably mediated by 3', 5'-cyclic AMP (cAMP) (Rosenblatt, 1982). For investigation of the role of cAMP in ...
Parathyroid hormone (PTH) acts on the kidney and bone through one common receptor in each organ. These actions, separately and together, serve to raise the blood calcium concentration. In the kidney, actions on the proximal tubule serve to decrease reabsorption of phosphorus and to activate the ...
Parathyroid Hormone and Parathyroid Hormone–Related Peptide Receptors Two types of parathyroid hormone (PTH) receptors have been identified. The type 1 PTH receptor (PTHR1) is activated by PTH and parathyroid hormone–related peptide (PTHrP) and mediates PTH effects in bone and kidney.399 In spite...
Maintenance of extracellular calcium homeostasis involves regulation of the responsiveness of the target cells to PTH by the hormonal milieu.doi:10.1016/S1569-2590(08)60112-3Abdul B. Abou-SamraAdvances in Organ BiologyAbdul B. Abou-Samra. . Parathyroid Hormone and Its Receptors. 1998:, 161-185....
Objectives The contribution of the clinical laboratory to diagnostics is increasingly important since a great deal of clinical decisions rely on laboratory test results. Content Parathyroid hormone (PTH) measurement presents a considerable analytical var
PP.31.23: HIGH AMBULATORY BLOOD PRESSURE VARIABILITY AND WORSE TARGET ORGAN DAMAGE ARE ASSOCIATED WITH ELEVATED PARATHYROID HORMONE LEVELS IN PATIENTS WITH HYPERTENSIONObjective: To assess the relationship between parathyroid hormone (PTH) serum levels and both blood...
As a result, calcium homeostasis is precisely regulated through the actions of parathyroid hormone (PTH), vitamin D, and calcitonin. Hypoparathyroidism is an endocrine disorder characterized by a deficiency in PTH, resulting in hypocalcemia and hyperphosphatemia. Causes include immune-mediated, ...
Metabolism of synthetic human parathyroid hormone (PTH) 2 X 10(-10) to 5 X 10(-9) M was studied in 16 isolated perfused rat kidneys and 12 isolated perfused rat livers. Organ clearances were measured by assays specific for intact PTH. Pr... H Daugaard,M Egfjord,K Olgaard - 《America...
hormone as isolated from parathyroid tissue; this has 84 amino acids and a molecular weight of ∼9500. There are two other populations of PTH fragments, one with a molecular weight of ∼7000 and one that is smaller, having a molecular weight in the range of 4500. Conflicting views are ...
or urinary phosphate in response to injected parathyroid extract (1). Albright speculated that this condition was owing to target organ (bone and kidney) resistance to PTH action, and dubbed this syndrome pseudohypoparathyroidism (PHP). This was the first description of hormone resistance in ...