hormone,secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue. Normally, various hormones are produced and secreted by the endocrine glands (seeendocrine system)...
Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide, synthesised by, stored within and released from the hypothalamus. It stimulates the synthesis and release of thyroid-stimulating hormone (TSH) and prolactin (PRL) from the anterior pituitary gland. In hyperthyroidism administration of ...
A common feature of hypothalamic-pituitary-endocrine systems is a closed feedback loop in which peripheral hormones secreted by the target organ exert inhibitory effects on the synthesis of their own hypophysiotropic hormone. Negative feedback regulation is also characteristic of the hypothalamic-pituitar...
USA; 2Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA Thyrotropin-releasing hormone (TRH) is a neuropeptide that initiates its effects in mice by interacting with two G-protein-coupled receptors, TRH receptor type 1 (TRH-R1) and TRH receptor type 2 (TRH-R2). ...
pituitary tumor induced by chronic estrogen treatment (Tashjianet al., 1968). As reported by Tashjianet al. (1970, 1971) and Gourdjiet al. (1972) for GH3cells, GH3B6cells secrete both PRL and, at a low level, growth hormone (GH), and they respond to TRH by an increase of PRL ...
The first one was identical to that previously found for intact GH3 cells. The present data show the existence of specific nuclear binding sites for TRH, establish their characteristics and suggest a possible nuclear site of action for that peptide hormone.FBournaudDGourdjiSMongonguA...