Background: Skin is a target organ and source of the corticotropin‐releasing hormone–proopiomelanocortin (CRH‐POMC) system, operating as a coordinator and executor of responses to stress. Environmental stress exacerbates and triggers inflammatory skin diseases through modifying the cellular components ...
Corticotropin-releasing hormone (CRH) neurons in the paraventricular hypothalamic nucleus (PVH) are in the position to integrate stress-related information and initiate adaptive neuroendocrine-, autonomic-, metabolic- and behavioral responses. In addition to hypophyseotropic cells, CRH is widely expressed...
2012, 2 136 Keywords: corticotropin-releasing hormone; anxiety; depression; psychiatric disorders; human polymorphisms; CRH receptors; CRH binding-protein 1. Introduction Corticotropin-releasing hormone (CRH) is a 41 amino acid peptide that was first isolated and characterized by Wylie Vale in 1981 [...
The cis-acting elements were classified as either hormone-specific elements (gibberellin-responsive elements, MeJA-responsive elements, auxin-responsive elements, salicylic acid-responsive elements, EREs, and ABREs) or abiotic stress-responsive elements (anaerobic responsive elements, TC-rich repeats, MYC,...