Biochemical cure/control of acromegaly results in a reduction in PTH target-organ sensitivity (as indicated by a significant increase in PTH and decrease in NcAMP and ACa concentrations), and may lead to the previously reported reduction in bone turnover. PTH target-organ sensitivity and phospho...
into the thyroid gland is an important step in the process of iodide organification and the formation of T3 and T4 (Dohan et al., 2003).Thyroglobulin (Tg) is a 660 kDa dimeric gycoprotein synthesized and secreted by thyroid cells and stored in the follicular lumen of the thyroid follicle...
The hypothalamus as an endocrine target organ The concept that the brain may be a target for hormone action originated with the pioneer studies of Berthold, who, in 1849, reported the striking changes in aggressive and sexual behaviour occurring... L Martini - Palgrave Macmillan UK 被引量: 3...
The goal of targeted delivery is to achieve an optimal concentration of an active agent to maximize exposure of target tissue, while remaining the levels in non-target tissues below the threshold of unacceptable organ toxicity and exposure. The inhibitor of the instant invention may bind and ...
As a central organ in lipid metabolism, the liver is likely to be affected by aberrant lipid metabolism. Furthermore, disorders of lipid metabolism demonstrate a significant correlation with HCC21–23. Therefore, due to the pivotal role of MAGL in lipid metabolism, its likely involvement in ...
Although the functional role of TSH in human HF biology awaits further dissection, these findings document that intracutaneous TSH-Rs are fully functional in situ and that HFs of female individuals are direct targets for nonclassical, extrathyroidal TSH bioregulation. This suggests that organ-...
However, our understanding of the human placenta is very limited and even more restricted is the knowledge of the impact of toxic substances in its development and fetal growth. So, could ethanol consumption during this period have wounding effects in the placenta, compromising proper fetal organ ...
Bull. World Health Organ. 82, 152–153 (2004). 12. Liang, G. et al. Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China. Emerg. Infect. Dis. 10, 1774–1781 (2004). 13. Shi, Z. & Hu, Z. A review of studies on animal ...
It is widely recognized that a Th1 response often plays an important role in cell-mediated immune response in organ-specific autoimmune diseases; however, the Th2 pathway is associated with hormone-mediated immunity and allergy [23]. During the effector phase of the immune response, miR-155 has...
Therefore, inactivation of these proteins may also be a viable strategy to alleviate the organ injury induced by COVID-19, which, as we have seen, depends heavily on dysregulation of that system. Precisely, the cited work [28] compared many NSAIDs in terms of their ability to interact with...