Clinical significance of drug binding, protein binding, and binding displacement drug interactions.Drugs widely used in clinical psychopharmacology, with few exceptions, are hepatically eliminated and circulate in the blood bound to plasma proteins. Often, the degree of is high (>90%). This fact ...
and appears to be useful for predicting changes in the disposition of rapidly metabolised compounds. Nevertheless, the state of knowledge about those factors which limit the rate of metabolism of individual drugs or classes of drugs is inadequate, and no general model or guidelines ...
Molecular weight, protein binding affinity and methane mitigation of condensed tannins from mangosteen-peel (Garcinia mangostana L) The main alterations in this regard relating to antibiotic concentrations are: (i) increased volume of distribution of drugs; (ii) increased cardiac output; (iii) increase...
Protein binding methotrexate derivative, and drugs containing the sameThe invention relates to methotrexate derivatives which contain a protein-binding group and can be enzymatically cleaved in the body such that the active substance or a ... クラッツ フェリックス,ワーネッケ アンドレ 被引量:...
4) drug-protein binding 药物-蛋白结合 1. Research on drug-protein binding is indispensable content in the study of early stage clinical pharmacokinetics of any new drugs. 一方面,药物的蛋白结合作用对其药理活性和药代动力学都有深刻的影响,因此深入研究药物-蛋白结合作用的分子基础具有重大的理论和实践...
The binding of 5 drugs to plasma proteins from patients with alcoholic liver disease has been studied by in vitro techniques and compared to that from normal subjects. The binding of quinidine is decreased in such patients. For this reason, if in patients with alcoholic liver disease treated for...
5.50.2.1.1 Protein binding Protein binding of drugs to plasma proteins such as human serum albumin has widespread pharmacokinetic implications: affecting clearance, the volume of distribution, and drug efficacy because it is the free fraction of the drug that is available to cross the BBB and is...
The detailed understanding of the binding of small molecules to proteins is the key for the development of novel drugs or to increase the acceptance of substrates by enzymes. Nowadays, computer-aided design of protein–ligand binding is an important tool to accomplish this task. Current approaches...
represents the binding information as a graph with two different types of nodes: one corresponding to proteins (also called targets, representing for example, human or viral proteins) and the other corresponding to ligands (representing potential drugs or natural compounds), respectively. A protein-...
Regenerative medicine has the potential to drastically change the field of health care from reactive to preventative and restorative. Exciting advances in stem cell biology and cellular reprogramming have fueled the progress of this field. Biochemical cues in the form of small molecule drugs, growth ...