Roepe PD. What is the precise role of human MDR 1 protein in che- motherapeutic drug resistance? Curr Pharm Des. 2000;6:241Y260.Roepe PD. What is the precise role of human MDR1 protein in che- motherapeutic drug resistance? Curr Pharm Des 2000; 6: 241-60...
Although target-based drug discovery is currently the dominant approach to drug discovery and development, the latest comprehensive assessment shows that its results are not as good as they could be. The number of drugs discovered by this approach is relatively small, and their therapeutic effects r...
Potential drug–drug interactions mediated by ATP-binding cassette (ABC) and solute carrier (SLC) transporters are of clinical and regulatory concern, but the endogenous function of these drug transporters is unclear. Nigam describes the evidence that th
Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease states, such as sepsis, the return flow of fluid from the interstitial space to the plasma...
The Drosophila trithorax protein is a coactivator required to prevent re-establishment of Polycomb silencing. Development 129, 2483–2493 (2002). CAS PubMed Google Scholar Klymenko, T. & Muller, J. The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group ...
HIV viral load tests look for RNA, the part of HIV that has the recipe for reproducing itself. They add an enzyme, a kind of protein, to make more copies of the RNA. This makes it easier to measure how much HIV is in your blood sample. ...
Is lectin the same as lecithin?No, they sound similar but are completely different things. While the former is a sugar-binding protein, the latter – lecithin – is a generic term for a broad category of yellowish-brown lipids (fats) found in plants and animals. ...
Vyondys 53 is an antisense oligonucleotide that works by binding to exon 53 of dystrophin pre-mRNA, which results in this exon being skipped over during mRNA processing. Skipping of exon 53 allows cells to join different exons together to produce a dystrophin protein that is shorter but has so...
This is still the Achilles heel of current computational drug-discovery efforts, and hence also poses problems when applying AI. We are able to describe chemistry rather well, and have a large amount of proxy assay data available for modelling, hence this type of data has been a key focus ...
The impact on human health is poorly understood and it is impossible to say what level of dietary exposure to acrylamide can be deemed safe as the assessment of exposure is uncertain. The determination of hemoglobin (Hb) adducts from acrylamide is increasingly being used to improve the exposure ...