This fact has led to a widespread belief that such drugs may frequently participate in interactions.: Coadministration of drugs can result in a highly bound drug displacing a less avidly bound drug from its sites. This leads to greater amounts of free, nonprotein-bound, drug available for ...
Discusses the significance of the human genome sequence to drug discovery. Importance of the DNA-array technology; Information on a gene index created by t... Grenet,O. - 《Pharmacogenomics Journal》 被引量: 2发表: 2001年 Structural diversity of G protein-coupled receptors and significance for ...
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosc...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed, and are known to interact with many other drugs in common usage by effects on protein binding, hepatic metabolism and renal clearance. NSAIDs can be prescribed in combination with all disease-modifying drugs in current use, ...
Understanding of the functional significance of the wide structural diversity of G-protein-coupled receptors (GPCRs) — one of the most important families of drug targets — has advanced considerably in recent years. This article provides a comprehensive
Kornguth ML, Monson RA, Kunin CM: Binding of antibiotics to a soluble protein from rat liver. Journal of Infectious Diseases 1974, 129: 552–558. Google Scholar Bryant RE, Hannond D: Interaction of purulent material with antibiotics used to treat pseudomonas infections. Antimicrobial Agents and...
Transport of the glutathione conjugates (GS-E) of electrophilic compounds generated during biotransformation of drugs and environmental pollutants is central to the mechanisms of defense against oxidative/electrophilic stress. In recent years emphasis has been placed on ATP-binding cassette (ABC) transport...
Sections were then washed in PBS, and incubated for 5 minutes in 1% Bovine Serum Albumin (BSA) to reduce non specific binding. The monoclonal antibodies for EBV CS1-4 (Dakopatts, diluted at 1:50) that recognizes EBV-encoded LMP1 and mouse anti-human Topoisomerase II α protein (DAKO, ...
Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment Article Immune regulation through tryptophan metabolism Introduction Trp, an essential amino acid not synthesized by the human body, must be obtained through diet [1,2,3,4,5]. It is a fundamental component of protein synthe...
The overactivation of ACSL4, LPCAT3, and LOXs produces a large amount of phospholipid peroxides, which trigger ferroptosis. Phosphatidylethanolamine-binding protein 1 (PEBP1) and arachidonate 15-lipoxygenase (ALOX15) can interfere with phospholipid alcohol synthesis and induce ferroptosis [5,52]. ALO...