protein and tissue binding, on pharmacokinetic parameters ‐ volume of distributionIntroductionFactors related to albuminFactors related to endogenous substancesFactors related to exogenous substancesDiseases influence drug–protein bindingEstimation of the extent of serum protein bindingTissue binding of drugs...
Protein Binding of Drugs Because only the free portion of a given drug is available to cross the placental barrier,protein bindingis an obvious and relevant covariate of placental drug passage. Albumin and α1-acidglycoproteinare the most importantplasma proteinsinvolved indrug protein bindingin plasm...
1) drug-protein binding 药物-蛋白结合1. Research on drug-protein binding is indispensable content in the study of early stage clinical pharmacokinetics of any new drugs. 一方面,药物的蛋白结合作用对其药理活性和药代动力学都有深刻的影响,因此深入研究药物-蛋白结合作用的分子基础具有重大的理论和实践意义...
relating to antibiotic concentrations are: (i) increased volume of distribution of drugs; (ii) increased cardiac output; (iii) increased hepatic and renal blood flow (and hence increased metabolism and excretion); and (iv) low serum protein levels, and hence altered protein binding of drugs (...
5.50.2.1.1Protein binding Protein bindingof drugs toplasma proteinssuch ashuman serum albuminhas widespreadpharmacokineticimplications: affecting clearance, the volume of distribution, and drug efficacy because it is thefree fractionof the drug that is available to cross theBBBand is, thus, responsible...
Protein binding of drugs in plasma are of special interest in pharmacological studies because only the drug that is unbound to plasma proteins (i.e., is “free”) has access to target tissue and hence is biological active18. PET imaging of the brain with radiolabeleld ligands faces the same...
... ) drug-protein 药物蛋白质 ) protein drug 蛋白质药物 ) Protein drugs 蛋白质药物 ... www.dictall.com|基于4个网页 2. 蛋白药物 蛋白药物,protein... ... ) drug-protein binding 药物蛋白结合 ) protein drug 蛋白药物 ) drug-protein 药物蛋白质 ... www.dictall.com|基于4个网页 3. 动物...
1)protein binding蛋白结合 1.High-performance capillary electrophoresis /frontal analysis and its Application to the protein binding study of chiral drugs;高效毛细管电泳/前沿分析及其在手性药性药物-蛋白结合研究中的应用 2.Pharmacokinetics and plasma protein binding of rutin deca (H-) sulfate sodium十取代...
Supervised prediction of drug–target interactions using bipartite local models. Bioinformatics 25, 2397–2403 (2009). Article Google Scholar Ballester, P. J. & Mitchell, J. B. O. A machine learning approach to predicting protein–ligand binding affinity with applications to molecular docking. ...
The meaning of PROTEIN is any of various naturally occurring extremely complex substances that consist of amino-acid residues joined by peptide bonds, contain the elements carbon, hydrogen, nitrogen, oxygen, usually sulfur, and occasionally other element