The effect of disease on the serum protein binding of phenytoin and propranolol, model drugs for weak acids and bases, respectively, was studied in dogs. Our preliminary investigations showed that, as in humans, the binding of organic bases is increased in diseases associated with stress and ...
At the level of molecular function, Simiao Powder has a great influence on protein binding, catalytic activity and transcriptional regulatory activity; at the level of cell components, Simiao Powder has a great influence on cells, mainly including cell parts, cytoplasm, organelles and cell membranes...
Recent studies on the intrinsic characteristics of protein ligand binding pockets find that there is a limited number (~1,000) in nature1,2, whereas the number of proteins in a typical proteome (e.g., in human ~20,000) is far larger. The implication is that a given protein target binds...
Lianhuaqingwen (LHQW) capsules reportedly inhibited SARS-CoV-2 replication and conferred anti-inflammatory activity in vitro-suppression of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-6, C-C motif ligand-2/Macrophage chemotaxis protein-1 and CXC motif chemokine ligand-10/Inducible...
Xolair works (mechanism of action) by blocking the binding of IgE to receptors on cells, which in turn stops the release of the chemicals responsible for allergy symptoms.Xolair also reduces the number of IgE receptors on cells, resulting in further improvement of allergy symptoms. ...
BACKGROUND: Although various drugs used by anesthesiologists highly bind to plasma proteins, the impact of iatrogenically induced hypoproteinemia on their pharmacologic effects has never been investigated. The authors determined the pharmacokinetics of ceftriaxone, a cephalosporin that binds strongly to albu...
protein restriction diet, high-salt diet, high-fat diet, and high-fiber diet, on cancer and the aforementioned diseases. We explore the multifaceted impacts of these dietary interventions, encompassing their immunomodulatory effects, other biological impacts, and underlying molecular mechanisms. This revi...
Vitamin D-binding protein DKK: Dickkopf transcription factor FDA: Federal Drug Administration FEM: Finite element methods or finite element analysis FLEX/FIT: Fracture Intervention Trial Long-Term Extension/Fracture Intervention Trial FREEDOM: Fracture Reduction Evaluation of Denosumab in Osteoporosis ...
On the other hand, miRNA headed by miR-105, because of its high cancer-to-normal secretion ratio in MCF10A extracellular vesicles, can reduce MXI1, a protein that can form a heterodimer with MAX. This MYC-MAX compound inhibits transcription of the MYC promoter, increases MYC protein levels ...
Metabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show t