Measurement and consideration of protein binding differences in animal models and patients are important for accurate translation to patients, especially when comparing data between rodents and humans. AI generated definition based on: Current Opinion in Pharmacology, 2017...
In subject area: Pharmacology, Toxicology and Pharmaceutical Science S100 is a calcium-binding protein that exists as α and β monomers (~10 kDa) that can form hetero- or homodimers (~20 kDa). From: Methods in Neurosciences, 1993
a protein backbone structure diffusion model trained independently and orthogonally to existing protein structure prediction networks, is confirmed by the X-ray structures of 16 designed proteins and a protein complex, and by experimental validation of designed heme-binding proteins and Ras-binding protein...
We employed in silico modeling and virtual screening techniques to identify small ligands for the PrP folding intermediate. First, we searched for druggable binding sites unique in the structure of the latter and not present in the native PrP conformation. This step was carried out by means of S...
As ligand binding-induced changes in Tm might be very small, methods must be able to reliably measure these changes. Depending on the method, a ΔTm over 1 °C can be counted as significant, but not all interactions give this high of a change. However, especially some covalent binders ...
We consider strong dominance (replacing ≥ with > in the above definition) on basin size and (negative) energy. One can now associate two additional quantities with each basin, Pareto Rank (PR) and Pareto Count (PC). The PR of a basin B is the number of basins that dominate B. The ...
This scenario includes three sub-categories: tissue-preferred hubs, tissue-specific hubs and tissue non-hubs. Tissue-preferred hubs are those that remain hubs in at least one tissue, while losing their hub status in other tissues. For example, AP19 (protein binding/protein transporter; AT2G17380...
Systems physiology, pharmacology and medicine Sections Figures References Abstract Background Results Discussion Conclusions Methods References Acknowledgements Author information Additional information Electronic supplementary material Authors’ original submitted files for images Rights and permissions About this artic...
The dictionary definition of “diet” and “dieting” is “to eat and drink sparingly or according to prescribed rules” or “a controlled intake of foods, as for medical reasons or cosmetic weight loss”. However, these definitions do not tell us anything about the two different aspects of ...
definition (relative path) for the "concentration" in the formula you set up but would have to decide of a "representative" concentration value, here. So this could e.g. be either the arterial or venous blood plasma concentrations (use the full absolute path definition (global reference point...