The uncertainty concerning the impact of plasma protein binding on a drug's pharmacological activity is, in part, related to the approach used when investigating and interpreting protein binding effects in vitro and in vivo. Frequently, a generalized one-size-fits-all approach, such as protein ...
plasma‐protein binding in drug researchIn broad terms, blood binding can either limit or favor the distribution of drugs to tissues. Blood binding can also direct drugs to their targets (receptors) in the plasma, blood cells or vessels. These various possibilities are presented here....
Conclusion:Breast cancer resistance is single protein cooperated with multi-proteins, but the coexpression of multi-proteins are most important. Combined drug-resistance-associated markers may help judge recurrence, metastasis and prognosis of patients with breast cancer. 展开 ...
Guanine nucleotide binding protein (G-protein)-coupled receptors (GPCRs) are eukaryotic transmembrane proteins found in all living organisms. Their versatility and roles in several physiological processes make them the single largest family of drug targets. Comparative genomic studies using various model ...
The effect of tenidap sodium on the disposition and plasma protein binding of phenytoin in healthy male volunteers. Br J Clin Pharmacol 1995; 39 Suppl. 1: 35S–38SPubMedCrossRef 56. Russell AG, Wilner KD, Hansen RA, et al. Lack of a significant interaction between tenidap and low dose...
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly upregulated by various inflammatory and immunological diseases, including several cancers, Alzheimer’s disease, and atherosc...
Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer ATP-binding cassette (ABC) transporter and DNA excision repair proteins play a pivotal role in the mechanisms of drug resistance. The aim of this study was... YH Kim...
need to be differentiated by CurveCurator. Each subplot shows one drug–protein interaction. The binding of a drug to a target leads to a depletion and, thus, a reduction in the relative response. Bold lines indicate clear down (red) or not regulated (gray) curves. Dashed lines indicate ...
It is proposed that 323 GPCRs could also represent drug targets, and ∼150 are still orphans. Abstract G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors and also the targets of many drugs. Understanding of the functional significance of the wide structural...
However, in the a protease K digestion experiment, there was no significant increase in the degradation rate of these tsRNAs after a prolonged digestion time, indicating the existence of a new mechanism contributing to tsRNA stabilization that is independent of protein binding. Finally, they ...