1995. What is the true clinical significance of plasma protein binding dis- placement interactions? Drug Saf 12:227-233.Sansom LN, Evans AM. What is the true clinical signif- icance of plasma protein binding displacement interac- tions? Drug Saf 1995;12:227-33....
OBJECTIVE:To investigate the expressions and clinical significance of ABCG2 and P-gp protein in the middle-late stage gastric cancer tissues.METHODS:The immunohistochemical method was used to detect the expressions of ABCG2 and P-gp protein in 60 cases of middle-late stage gastric cancer tissues...
Expression and clinical significance of cold-induced RNA-binding protein in lung adenocarcinoma analyzed based on bioinformatics. Chinese Journal of Thoracic and Cardiovascular Surgery, 2022, 29(7): 914-922. doi: 10.7507/1007-4848.202102065 梁诗琪, 刘雨薇, 林琳, 等. 上消化道手术患者术前肺功能...
The tumour microenvironment is hypoglycaemic, hypoxic and acidotic. This activates a stress signalling pathway: the unfolded protein response (UPR). The UPR is cytoprotective if the stressor is mild, but may initiate apoptosis if severe. Activation of th
In addition to the usual age cutoff for adults at 18 years, we performed a cutoff-free mutation enrichment analysis (Fig.3B). Enrichment tests (see “Methods”) confirmed the significance of age biases in genes determined by the Fisher tests above. However, gene mutation densities over age re...
Multiple submicroscopic genetic alterations with prognostic significance have been discovered, including internal tandem duplication of the FLT3 gene, mutations in the NPM1 gene, partial tandem duplication of the MLL gene, high expression of the BAALC gene, and mutations in the CEBPA gene. Application...
To investigate the clinical significance of PIK3R2 in TETs, we performed IHC staining on obtained TC tissues and adjacent normal thymic tissues. The staining score of PIK3R2 in TC tissues was confirmed to be higher than that in the corresponding normal counterparts (Figure S6b-d). We additiona...
(largely gene mutations and a small number of fusions) assessed the transforming activity of 158 FGFR mutations, in comparison to the respective WT FGFR. Importantly, of 122 variants of unknown significance (VUS) tested, 25 were determined to be oncogenic or likely oncogenic (Table1), ...
Antibiotic stewardship programs, which emphasize dosing regimen and duration of therapy options, are increasing awareness of appropriate use of antibiotics. Personnel from these programs should be able to describe the significance to clinicians of an SDD result for cefepime. How should this change...
Annexin A2 (ANXA2), a 36 kDa membrane protein on cell surface, is a member of calcium-dependent phospholipid-binding protein family, which is widely expressed in various eukaryotic cells. Previous researches have identified that ANXA2 is involved in cell angiogenesis, invasion, proliferation and me...