The uncertainty concerning the impact of plasma protein binding on a drug's pharmacological activity is, in part, related to the approach used when investigating and interpreting protein binding effects in vitro and in vivo. Frequently, a generalized one-size-fits-all approach, such as protein ...
-9, IL-6, cluster of differentiation 14 (CD14), S100 Calcium Binding Protein A6 (S100A6), and S100A4 (Fig.4bupper panel). The lower panel of Fig.4billustrates the liver cancer signaling pathway between CHI3L1 and its target proteins. Overall, the association between CHI3L1 and these target...
To investigate the prognostic value of heart-type fatty acid binding protein (H-FABP) in patients with stable coronary heart disease (SCHD). A total of 1,071 patients with SCHD were prospectively enrolled in this Taiwan multicenter registry study, followed for 24 months. The cut-off value of...
In the cytosol, retinoid binding proteins, cellular retinoic acid-binding protein and cellular retinol-binding protein, have been correlated with normal and ... M Cornic - 《Cancer Research》 被引量: 269发表: 1992年 Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retin...
In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for viral origin Sakshi Piplani 1,2 , Puneet Kumar Singh 2 , David A. Winkler 3-6 *, Nikolai Petrovsky 1,2 * 1 College of Medicine and Public Health, Flinders University, Bedford Park...
Melatonin, the ‘hormone of darkness’ is a neuronal hormone secreted by the pineal gland and other extra pineal sites. Responsible for the circa
C-C Motif Chemokine Receptor 2 (CCR2) plays a critical role in immune cell chemotaxis to monocyte chemoattractant protein-1 (MCP-1), a chemokine that specifically mediates monocyte chemotaxis. MCP-1 is upregulated in tissue injury such as myocardial infarction and directs the mobilization of mon...
Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA. 5 adjuvant trial. Breast Cancer Res. Treat. 2011, 128, 401. [Google Scholar] [CrossRef] Zhong, W.; Yang, Y.; Zhang, A.; Lin, W.; Liang...
BMC Nephrology (2020) 21:459 https://doi.org/10.1186/s12882-020-02122-y RESEARCH ARTICLE Open Access Significance of urinary fatty acid-binding protein 4 level as a possible biomarker for the identification of minimal change disease in patents with nephrotic-range proteinuria Marenao Tanaka1†,...
ATP-binding cassette (ABC) transporters are members of a protein superfamily which can be responsible for efflux of drugs from cells of target organisms. In this way, the transporters may provide a mechanism of protection against cytotoxic drugs. In laboratory-generated mutants of fungi, ...