The uncertainty concerning the impact of plasma protein binding on a drug's pharmacological activity is, in part, related to the approach used when investigating and interpreting protein binding effects in vitro and in vivo. Frequently, a generalized one-size-fits-all approach, such as protein ...
The purpose of this study was to evaluate the correlation between calcium‐binding protein S100A8 and S100A9 expression in non‐small cell lung cancer (NSCLC) and patients' clinical features. Fifty‐two NSCLC patients who underwent surgery at Zhejiang Hospital from February 2014 to January 2016 wer...
An unusual pattern in a nucleic acid or protein sequence or a region of strong similarity shared by two or more sequences may have biological significance... S Karlin,SF Altschul - 《Proc Natl Acad Sci U S A》 被引量: 2955发表: 1990年 Predicting protein interaction sites: binding hot-spo...
According to the lamin database (http://www.dmd.nl/lmna_home.html#protein)30, 1B domain originates from Tyr 81 and terminates at Thr 218. We analyzed the coiled-coil forming propensity of this region using PCOILS server31. Based on the heptad repeat formation prediction from COILS/PCOILS...
APOBEC1 is expressed in the small intestine and edits mRNA to enable tissue-specific expression of a truncated but functionally important gastrointestinal protein [7,8,9]. APOBEC3s are much more widely expressed across human tissues and deaminate—and thereby damage—viral genomes as part of the ...
In addition to its caveolae formation abilities, Cav-1 acts as a scaffold and signaling protein known to interact with a wide variety of client proteins. In cardiovascular cells and tissues, studies have shown direct caveolin binding to and modulation of growth factor and G protein-coupled recepto...
There is variability in the reported incidence of FGFR2 overexpression in GC; FGFR2 protein overexpression was reported to be 30%–40% by immunohistochemistry, (Hattori et al, 1996) while the incidence ofFGFR2amplification varies from 3 to 10% (Mor et al, 1993;Hara et al, 1998;Deng et ...
High metabolic activity is a hallmark of cancers, including hepatocellular carcinoma (HCC). However, the molecular features of HCC with high metabolic activity contributing to clinical outcomes and the therapeutic implications of these characteristics ar
MiR-1 is involved in the growth and development of cardiomyocytes by reducing the expression of GATA-binding protein 4 (GATA4) and calmodulin Mef2a, which regulate the calcium signal pathway and protein expression and could be targeted for diagnosis and therapy [79]. 2.1. miRNAs and HF HF ...
ATP-binding cassette (ABC) transporters are members of a protein superfamily which can be responsible for efflux of drugs from cells of target organisms. In this way, the transporters may provide a mechanism of protection against cytotoxic drugs. In laboratory-generated mutants of fungi, ...