The uncertainty concerning the impact of plasma protein binding on a drug's pharmacological activity is, in part, related to the approach used when investigating and interpreting protein binding effects in vitro and in vivo. Frequently, a generalized one-size-fits-all approach, such as protein ...
Nishikawa M, Miyake H, Behnsawy HM, Fujisawa M. Significance of 4E-binding protein 1 as a therapeutic target for invasive urothelial carcinoma of the bladder. Urol Oncol. 2015; 4:166.e9-15.MasatomoNishikawa, HideakiMiyake, Hosny M.Behnsawy, MasatoFujisawa. (2015) Significance of 4E-binding...
Objective To investigate the expressions of Insulin-like growth factor 1 and Insulin like growth factor binding protein 3 in serum and bronchoalveolar lava... XU Ping,PI Jiali,Y Liu - 《Journal of Clinical Internal Medicine》 被引量: 13发表: 2007年 Characterisation of protein families in spider...
Significance of antigen binding by T cells 来自 Semantic Scholar 喜欢 0 阅读量: 22 作者:J Charreire,JF Bach 摘要: Using a previously developed in vitro model of sensitization of lymphoid cells against monolayers of syngeneic thyroid epithelial cells, the T or B nature of the population involved...
Significance of fascin expression in laryngeal squamous cell carcinoma. Larynx NeoplasmsSquamous Cell CarcinomaObjective: Fascin is an actin-binding protein which is expressed in the basal areas of healthy squamous epithelium. ... DURMAZ,A.,KURT,... - 《Journal of Laryngology & Otology》 被引量:...
The serum levels of the low molecular form of insulin-like growth factor binding protein (IGFBP) was determined in 56 outpatients with diabetes mellitus by a radioimmunoassay developed for amniotic 35 kDa IGFBP. The mean level of 35 kDa IGFBP was found to be threefold higher in insulin ...
Significance of the ligand-binding affinity of the Sho1 SH3 domain for in vivo function. 来自 掌桥科研 喜欢 0 阅读量: 11 作者: JA Marles 摘要: Quantitative understanding of how the strength of a protein-protein interaction is related to its biological function is a prerequisite for modeling ...
Levels of oxDJ-1 were higher in unmedicated patients with PD (142.2 ± 21.8 ng oxDJ-1/mg protein; n = 13) compared to the L-DOPA-treated group (85.6 ± 10.1 ng oxDJ-1/mg protein; n = 10) and controls (56.0 ± 6.2 ng oxDJ-1/mg protein; n = 17), thereby showing ...
摘要: Iron is carried in blood plasma by the protein transferrin, which is able to carry two atoms of iron. The availability of bound iron to immature red blood cells seems to vary according to the way in which the iron is distributed on the molecule of transferrin....
Silencing of telomere-binding protein adrenocortical dysplasia homolog (ACD) enhances radiosensitivity in glioblastoma cells Silencing of ACD led to the enhanced radiation sensitivity, decreased telomerase activity and cyclin D1 expression, reduced expression of BIRC1, and finally... P Francesca,C Maria,...