Clinical significance of drug binding, protein binding, and binding displacement drug interactions. Pshy- chopharmacol Bull 36(3):5-21.DeVane, C.L. Clinical significance of drug binding, protein binding, and binding displacement drug interactions. Psychopharmacol. Bull. 2002, 36, 5-21. [PubMed...
Review of the penetration of antibiotics into CSF, and its clinical significance. Scandinavian Journal of Infectious Diseases 14 (Suppl.): 296–309, 1978 PubMed CAS Google Scholar Reitberg DP, Cumbo TJ, Smith IL, Schentag JJ. Effect of protein binding on cefmenoxime steady state kinetics ...
An unusual pattern in a nucleic acid or protein sequence or a region of strong similarity shared by two or more sequences may have biological significance... S Karlin,SF Altschul - 《Proc Natl Acad Sci U S A》 被引量: 2955发表: 1990年 Predicting protein interaction sites: binding hot-spo...
Furthermore, we find that the average shortest path lengths are highly correlated with residue fluctuations, providing a link between the spatial arrangement of the residues and protein dynamics. 展开 关键词: Proteins Amino Acids Protein Binding Kinetics Binding Sites Amino Acid Sequence Computer ...
Human bladder carcinoma cells with an unusual pattern of in vitro growth: transition from nonproliferative spheroids to active monolayer growth upon intera... of MHC-class I, S100 protein, cytokeratin CK7 and CK20, beta-HCG, CEA, epithelial membrane antigen, Le(y) and folate-binding protein by...
Further promoter analyses led to the identification of a putative cis-regulatory element in each promoter matching the consensus DNA binding site for Antirrhinum CYC protein: GGCCCCTC at 165 for ChCYC1C, and GGCCCCCC at 163 for ChCYC1D. This indicates that both the ChCYC1C and ChCYC1D ...
Iron is carried in blood plasma by the protein transferrin, which is able to carry two atoms of iron. The availability of bound iron to immature red blood cells seems to vary according to the way in which the iron is distributed on the molecule of transferrin. This is a preview of subscr...
Objective To explore the relationship of expression of C-erbB-2 oncogene protein,EGFR (Epidermal growth factor receptor) and TGF-β 1 (Transforming growth factor-β 1 ) to the progression/metastases of pancreatic cancer. Methods Using streptoaduidinbiotin complex (SABC) method,C-erbB-2 oncogene...
摘要: Iron is carried in blood plasma by the protein transferrin, which is able to carry two atoms of iron. The availability of bound iron to immature red blood cells seems to vary according to the way in which the iron is distributed on the molecule of transferrin....
Guanine nucleotide binding protein (G-protein)-coupled receptors (GPCRs) are eukaryotic transmembrane proteins found in all living organisms. Their versatility and roles in several physiological processes make them the single largest family of drug targets. Comparative genomic studies using various model ...