The renoprotective action of PPAR agonists is also widely observed in non-diabetic kidney diseases as well as in cultured renal cells including podocytes. Accumulating evidence suggests that within the kidney, podocytes may represent the major target cell type of PPAR. The goal of this review is ...
PPAR Signaling PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids. Search Report on Emergency Response Control over 33 Main Posted onDecember 21, 2024 Reply The CE Studio Team held five sessions with each of four neighborhood expert panels (total of ...
Thiazolidinediones (TZDs), which act through the nuclear receptor peroxisome proliferator activated receptor-γ (PPARγ), are a widely prescribed class of drugs for type 2 diabetes; however, their use has been challenged by a number of side effects. Here
Alternatively, biased GPR40 agonists might be sought that activate both p38 MAPK and PPARγ, but not ERK1/2, avoiding its harmful effects on PPARγ signaling, insulin resistance and inflammation. Such next generation drugs might be useful in treating not only type 2 diabetes, but also diverse...
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Reply Minimal thyroid function and reduced waste metabolized because of the kidneys in clients with MDD advise a low consumption and reduced metabolic rate in despondent patients. In inclusion, simplegenetic etiologyvariations in the anion space in despondent clients had been highly correlated with the...
PPAR signaling in the control of cardiac energy metabolism. Thus, PPARα not only serves a critical role in normal cardiac metabolic homeostasis, but alterations in PPARα signaling likely contribute to the ... PM Barger,DP Kelly - 《Trends in Cardiovascular Medicine》 被引量: 1419发表: 2000年...
The PPAR signaling pathway plays an essential role in trophoblastic cell fusion, migration, angiogenesis, lipid metabolism, and trophoblastic cell cycle progression, and its overactivation suggests complex biological functions, including placental immune tolerance, trophoblastic cell invasion, syncytium ...
We found that the TNF-α/IL-1-activated TAK1/TAB1/NIK (NFκB-inducible kinase) signaling cascade inhibited both the adipogenesis and Tro-induced transactivation by PPAR-γby blocking the receptor binding to the cognate DNA response elements. Furthermore, it has been shown that the noncanonical...
In conclusion, our results indicate that a downregulation of proteins involved in PPAR signaling and the modulation of several cancer-related proteins are associated with the ... MP Simula,R Cannizzaro,V Canzonieri,... 被引量: 1发表: 2010年 Do gliadin and tissue transglutaminase mediate PPAR ...