PPAR signaling pathway overview Like other nuclear receptor super families, PPAR is essentially a class of ligand-dependent transcriptional regulators, all of which are single subunits with an N-terminal region (A/B region), a highly conserved DNA-binding region (C region), and the hormone ...
PPARγ signaling and metabolism: the good, the bad and the future[J]. Nature Medicine,2013,19(5):557-66. [10] Sugii S,Olson P,Sears D D,et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization[J]. Proc Natl Acad Sci U S A,2009,106(52):22504-9....
PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol. Metab. 23, 351–363 (2012). Article CAS PubMed Google Scholar Lee, C.H. & Evans, R.M. Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis. Trends Endocrinol. Metab. 13, 331–335 (...
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PPAR signaling in the control of cardiac energy metabolism: Lessons from genetically altered mice related receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal ... Daniel,P.,Kelly,... - 《Journal of Mole...
The PPAR signaling pathway plays an essential role in trophoblastic cell fusion, migration, angiogenesis, lipid metabolism, and trophoblastic cell cycle progression, and its overactivation suggests complex biological functions, including placental immune tolerance, trophoblastic cell invasion, syncytium ...
Pelletier JP. The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the in...
2019年,合肥工业大学的Lijun Tu等人,在《Food and Chemical Toxiclolgy》杂志(IF2018=3.977,工程技术2区)上发表了题为“Red raspberry extract (Rubus idaeus L shrub) intake ameliorates hyperlipidemia in HFD-induced mice through PPAR signaling pathway”的文章,文章对红树莓提取物(RRE)对高脂血症小鼠降血脂作...
PPARγ and PGC1α signaling: role of NRF2, estrogen related receptor and irisin As mentioned above, PGC1α is classified as a transcription coactivator and is considered a principal controller of mitochondrial biogenesis that plays a vital role in the regulation of cellular energy metabolism (Austin...
Abstract 5718: Convergence of vitamin D and PPAR signaling in human breast cancer cell linesPrevious studies have demonstrated a positive interaction between vitamin D and peroxisome proliferator- activated receptor γ (PPARγ) mediated ... F Alimirah,RG Mehta,X Peng - 《Cancer Research》 被引量...