Combination PPAR- gamma agonist and immunosuppressive drugs for the treatment of undesirable immune responsesA method for treating or preventing undesirable immune response, comprising administering concurrently with immunosuppressants such as cyclosporin, rosiglitazone or pioglitazone and PPAR- gamma agonist. ...
These mechanisms provide a base for designing drugs. Further, the ligand-dependent mechanism comprises an agonist or antagonist mode of activation. The agonist mode may be full or partial depending on the structural differences and activation profile. Full agonist activity includes binding of ligand ...
PPARG A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, an...
in a greater upregulation of serum adiponectin levels than did administration of at least 22 times the amount of pioglitazone. Small amounts of INT131 are at least as efficacious in treating diseases in which adiponectin levels are reduced as are other drugs which also increase adiponectin levels...
- 《Cns Drugs》 被引量: 38发表: 2014年 Therapeutic potential of aleglitazar, a new dual PPAR-alpha/gamma agonist: implications for cardiovascular disease in patients with diabetes mellitus. Preventing morbidity and mortality from diabetes mellitus is of paramount importance as the incidence of ...
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model. Thiazolidinediones are insulin-sensitizing drugs, ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which play an important role in the modulation...
摘要: Describes the identification and role of PPAR-gamma, a member of the nuclear hormone receptor superfamily, as a central regulator of fat cell differentiation. Function of PPAR-gamma as the major receptor for the thiazolidine class of insulin-sensitizing drugs; Evidence implicating the protein ...
Mifepristone, a PPAR gamma agonist, has also been shown to protect against cerebral ischemia [33]. PPAR gamma also activates the (SOCS) suppressor of cytokine signalling [34]. Increased SOCS 3 expression is associated with reduced IL-6 and TGF-1 expression, oedema formation, and vacuolization,...
These drugs have been further tested in human breast, prostate, and colon cancer cells resulting in inhibition of cell proliferation [11]. There is great interest in the use of TZDs as chemopreventive agents in a variety of malignancies including liposarcomas and cancers of the breast, colon ...
ammatory drugs; PPAR, peroxisome proliferator-activated receptor; PPRE, peroxisome proliferator response element; PGs, prostaglandins; PI3-kinase, phosphatidylinositol 3-kinase; ROS, reactive oxygen species; RXR, retinoid X receptor. ?ow control, immune responses, ovulation, bone development, wound ...