Chen, Agonist-PPAR g interactions: molecular modeling study with docking approach, International Journal of Quantum Chemistry 93 (2003) 405e410.Xiao Ying Xu,,Feng Cheng,Jian Hua Shen,Hua Liang Jiang et al.Agonist-PPARγ interactions : Molecular modeling study with docking approach. International ...
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes Bioorg. Med. Chem. Lett. (2009) A. Bugge et al. PPAR agonists, - Could tissue targeting pave the way? Biochimie (2017) P. Cronet et al. Structure of the PPARalpha and -gamm...
PPAR-alpha and -gamma agonist for the treatment of animal model of non-alcoholic fatty liver disease is effective in improving histological and biochemical changes 喜欢 0 阅读量: 29 作者: Yeon,J,Choi,K,Baik,S,Chang,Y,Lee,Seo 关键词: - ...
Unlike rosiglitazone. chiglitazar showed significant increase of mRNA expression involved in EFA oxidation.CONCLUSION : Chiglitazar may have better effects on lipid homeostasis in diabetic patients than selective PPARgamma agonist. 展开 会议名称: 《第十五届国际药理学大会论文集》 会议时间: 2006年 ...
A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR{gamma}) Recruits PPAR{gamma}-Coactivator-1{alpha}, Prevents Triglyceride ... B Elke,S Astride,F Angele,... - 《Molecular Endocrinology》 被引量: 243发表: 2006年 A novel insulin sensitizer acts as a coligand...
Interestingly, pretreatment with a PPARα agonist markedly prevents the LPS-induced increase of plasma IL-1, IL-6, and TNF, and the expression of adhesion molecules, such as ICAM-1 and VCAM-1 in the aorta, suggesting that liver PPARα controls, in a yet undefined manner, the systemic ...
Seladelpar (LIVDELZI®) is an oral delpar [i.e. a selective peroxisome proliferator-activated receptor (PPAR)δ agonist] being developed by Gilead Sciences for the treatment of primary biliary cholangitis (PBC). On 14 August 2024, based on a reduction in alkaline phosphatase (ALP), it re...
Current Progress on Peroxisome Proliferator-activated Receptor Gamma Agonist as an Emerging Therapeutic Approach for the Treatment of Alzheimer’s Disease: An Update. Curr. Neuropharmacol. 2019, 17, 232–246. [Google Scholar] [CrossRef] Toobian, D.; Ghosh, P.; Katkar, G.D. Parsing the Role...
Adhikary, T. et al. The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.Nucleic Acids Res.43, 5033–5051 (2015). ArticleCAS Lefterova, M. I. et al. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a ...
Those genes induced selectively by one agonist, but not the other, showed weaker enrichment for these pathways, particularly considering the smaller number genes regulated by both drugs. These data suggest that PPARγ agonists have stronger effects on BAT than PPARα agonists, yet those genes ...