The breakdown of protein appears to follow a similar rate (1). Protein synthesis and degradation however, are only the two extremes of a complex phenomena which includes a variety of other protein modifications. Proteolytic cleavage is the most common covalent modification of proteins; probably all...
unidirectional reactionspolypeptide chain alterationssecondary amino acidsRadha G. KrishnaDepartment of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TXFinn WoldDepartment of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX...
These alterations include DNA methylation, histone modifications, histone acetylation, and RNA interference [1]. Post-translational modification (PTM) of proteins is the chemical modification of specific amino acid residues, which is ubiquitous in mammalian cells and plays a crucial role in the ...
2022b), suggesting that these PTMs may link dysregulated brain glucose metabolism to pathological alterations in AD. In conclusion, various PTMs regulate the pathogenesis of AD and provide insights into potential therapeutic targets for AD. Role of PTMs in atherosclerosis (AS) AS is characterized ...
Overview of protein PTMs Protein PTMs is a covalent modification that occurs in the backbone or side chain of a protein after translation and may alter protein physicochemical properties, spatial conformation, stability, cellular localization, and interactions with other proteins, greatly enriching the ...
The second category of inhibitors, namely, KDAC inhibitors, inhibits the activity of deacetylases and increases the acetylation level of proteins. For instance, treatment with pan-HDAC inhibitor, vorinostat, may induce cell cycle arrest and cell apoptosis in breast cancer cells [73]. Tubacin is a...
Posttranslational modifications(PTMs) are basically a chain of reversible or irreversible chemical alterations of proteins that occur after the completion of translational process. The modification affects both structure and functions of protein and makes it more diverse. This makes coding of eukary...
While the foundation of the structural and functional diversity of a cell’s proteome lies in the gene-encoded primary polypeptide sequences of proteins, this basic framework is vastly enriched by alternative splicing of transcripts, as well as a wide array of post-translational alterations. The ...
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and ...
Cancer Research: Studying PTMs in cancer cells helps understand tumorigenesis and identify novel targets for cancer therapy, as many cancer-related proteins undergo abnormal modifications. Neuroscience: PTMs are critical in studying neurodegenerative diseases and brain function, as alterations in protein ph...