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More than 200 diverse types of PTMs are currently known (5,6), ranging from small chemical modifications (e.g., phosphorylation and acetylation) to the addition of complete proteins (e.g., ubiquitylation, Figure 3). Phosphorylation Protein phosphorylation (Figure 2) is the most commonly ...
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological processes. Although the classical PTMs, such as phosphorylation, acetylation, ubiquitination and methylation, have be...
Protein domains play a fundamental role in the spatial and temporal organization of intracellular signaling systems. While protein phosphorylation has long been known to modify the interactions that underlie this organization, the dynamic cycling of lipids should now be included amongst the posttranslation...
W. A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat. Chem. Biol. 9, 416–421 (2013). Article CAS PubMed PubMed Central Google Scholar Stancik, I. A. et al. Serine/threonine protein kinases from bacteria, archaea and eukarya share a common evolutionary...
Posttranslational protein S-palmitoylation and the compartmentalization of signaling molecules in neurons. Protein domains play a fundamental role in the spatial and temporal organization of intracellular signaling systems. While protein phosphorylation has long... Sean,I,Patterson - 《Biological Research》 ...
Protein post-translational modifications (PTMs) increase the functional diversity of the proteome by the covalent addition of functional groups or proteins, proteolytic cleavage of regulatory subunits, or degradation of entire proteins. These...
Tyrosine phosphorylation, S-nitrosylation and S-glutathionylation were analyzed, both at the cellular level (flow cytometry and fluorescence microscopy analysis) and at the protein level (redox proteomics and Western blot analysis), to effectively visualize and find links between the studied ...
Protein post-translational modification plays an important role in organism. It makes the protein obtain more complicated structures, perfect functions, more accurate regulations and more spe-cific operations. The most common protein post- translational modifications include ubiquitylation, phosphorylation, gl...