Protein post-translational modification (PTM) by glycosylation and lipidation rely on the spatiotemporal colocalization of enzyme, substrate, and glycan or lipid donor molecule and do not require an upstream "blueprint" or specialized processing machinery for synthesis. Glycan and lipid PTMs can thus...
Myristoylation: An Important Protein Modification in the Immune Response. Front Immunol. 2017;8:751. Article PubMed PubMed Central Google Scholar Resh MD. Fatty acylation of proteins: The long and the short of it. Prog Lipid Res. 2016;63:120–31. Article CAS PubMed PubMed Central Google...
SUMO-E2 conjugating enzyme, and SUMO-E3 protein ligases to covalently attach the small ubiquitin-related modifier (SUMO) proteins to the lysine residues of the target proteins [9,131]. Sumoylation is a reversible modification that can be deSUMOylated by SUMO-specific...
SUMO-E2 conjugating enzyme, and SUMO-E3 protein ligases to covalently attach the small ubiquitin-related modifier (SUMO) proteins to the lysine residues of the target proteins [9,131]. Sumoylation is a reversible modification that can be deSUMOylated by SUMO-specific...
Post-translational modification can occur at any step in the "life cycle" of a protein. For example, many proteins are modified shortly after translation is completed to mediate proper protein folding or stability or to direct the n...
Protein phosphorylation (Figure 2) is the most commonly studied post-translational modification. It has been estimated that one-third of mammalian proteins may be phosphorylated, and this modification often plays a key role in modulating protein function. Phosphorylation takes place on serine, threonine...
protein processingphosphopeptide sequencingaffinity enrichmentThe elucidation of posttranslational modification of proteins is a prerequisite for understanding the molecular details of living organisms, from bacteria to plants and mammals. Protein phosphorylation plays a key role in cell signaling during cellular...
Post-translational modifications play a critical role in regulating protein function. Increasingly, determination of protein identity, estimation of abundance, and characterization of post-translational modifications are required for analysis of protein-mediated cell signaling networks. As such, we report an...
Post-translational modification can occur at any step in the "life cycle" of a protein. For example, many proteins are modified shortly after translation is completed to mediate proper protein folding or stability or to direct the nascent ...
Comprehensive and cutting edge, the book serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries. 展开 关键词: Post translational modification ...