Plasma cells produce largequantities of antibodies and so play essential roles in immune protection1. Plasma cells, including a long-lived subset, reside in the bone marrow where they depend on poorly defined microenvironment-linked survival signals1. We show that bone marrow plasma cells use the ...
Osteoblast-derived ATP maintains bone marrow plasma cells Plasma cells use P2RX4 to sense the regulated release of ATP from osteoblasts and this protects against ER stress-driven apoptosis. Yvonne Bordon Research Highlights29 Feb 2024 Nature Reviews Immunology Volume: 24, P: 231 Tissues of orig...
24小时服务热线 info@ldraft.com; sales@ldraft.com; marketing@ldraft.com销售邮箱 prevnext 货号:ABC-1170 价格:¥询价 规格: 1 vial 数量:-+ 产品描述 参考文献 资料下载 相关产品 产品描述/Products Description Non-human primate-Plasma is processed through centrifugation to diminish cells and platelets...
Fig. 1. Most of plasma cells that arrive at bone marrow are short-lived B220(hi) MHC-II(hi) cells. A small fraction of them become immobilized to bone marrow niches and progressively differentiate into long-lived B220(lo) MHC-II(lo) cells. Credit: Koike et al. Just as a fire depar...
Plasma cells are the immune system cells responsible for producing antibodies, the key mediators of protective humoral immunity. Long-lived plasma cells (PC) are thought to be responsible for maintaining antibody titers and are believed to populate unique survival niches in the bone marrow (BM). ...
Plasma cells(PC) are terminally differentiated and nondividingimmune cellsarising from B cells whose primary function is to secrete antibodies to fight infection.1–3PCs can live for a long period, even a lifetime, in the bone marrow if survival signals, such as interleukin (IL)-6, A prolif...
In a multivariate analysis using the bone marrow plasma cell labeling index and β2-microglobulin, the absolute number of plasma cells in the stem cell harvest achieved borderline significance for predicting relapse-free survival (P = 0.057). In conclusion, increased monoclonal plasma cells in the ...
Description:Mantle Cell Lymphoma-Plasma is obtained by centrifugation of blood tissues. Mantle Cell LymphomaPlasma is available in the untreated and relapsed/refractory stages.; Quality Control:All cells test negative for mycoplasma, bacteria, yeast, and fungi; Application:For research use only....
The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology ...
two-thirds of all plasma cell dyscrasias. By definition, it is a laboratory abnormality describing a serum monoclonal protein level usually less than 3 g/dL, greater than 10% monoclonal plasma cells in the bone marrow, low or absent levels of monoclonal protein in the urine, and no systemic...