Impact of bone marrow plasma cells percentage on survival at diagnosis and pre-transplant period in newly diagnosed multiple myeloma: Experience of a single center from TurkeyAutologous stem cell transplantationBone marrow plasma cellMultiple myeloma...
BJBain, inBlood and Bone Marrow Pathology (Second Edition), 2011 Plasma cells There are less than 1–2% ofplasma cellsin normal BM. An increased percentage of BM plasma cells may be found in a wide range of pathologic conditions (Box 5.2). In various non-neoplastic conditions, up to 50%...
plasma cell (redirected fromPlasma cells) Thesaurus Medical Encyclopedia Related to Plasma cells:Macrophages,Histiocytes,Memory cells n. Any of various short-lived cells that develop from activated B cells and secrete large numbers of antibodies. They are found chiefly in the bone marrow, spleen, ...
8 Effects of bortezomib-mediated meningeal plasma cell depletion on bone marrow and spleen compartments. a, Gating strategy for flow cytometric analysis of spleen and bone marrow plasma cells in the protocol depicted in Extended Data Fig. 5b. b, Representative flow cytometric plots showing CD138+ ...
Interestingly, mir-17–92-deficiency in B cells leads to enhanced homing of plasma cells to the bone marrow during T-cell-dependent immune response and selectively impairs IgG2c production. Mechanistically, mir-17–92 directly represses the expression of Sphingosine 1-phosphate receptor 1 and ...
In a multivariate analysis using the bone marrow plasma cell labeling index and β2-microglobulin, the absolute number of plasma cells in the stem cell harvest achieved borderline significance for predicting relapse-free survival (P = 0.057). In conclusion, increased monoclonal plasma cells in the ...
Practical guidance on diagnostic and prognostic use of next generation sequencing (NGS) in multiple myeloma (MM) and other plasma cell neoplasms (PCN) has yet to be developed. To this end, we analyzed the correlation of NGS data with the degree of bone marrow (BM) plasma cell (PC) involve...
Circulating monoclonal plasma cells were quantified as a percentage of circulating cytoplasmic immunoglobulin-positive cells (PBPC%). The absolute circulating plasma cell count was also determined. When analyzed retrospectively, 24 (16%) of 147 patients were found to have detectable circulating PBPCs. ...
Table 1. Percentage of Plasma Cells and Suppression of Pre-B Cells in the BM Case No.M-proteinBM (%) Plasma CellsPre-B Cells Empty Cell IsotypeSerumCD19-CD19+ Empty Cell MM 1 IgG 1,940 14 0 1 2 IgG 5,190 10 0 0 3 IgG 9,660 18 0 0 4 IgG 5,530 25 0 1 5 IgG...
Smolderingmyeloma(SMM) is a premalignantplasma cell dyscrasia, which is intermediate between MGUS and MM.SMMis differentiated from MGUS by higher serum monoclonal protein levels (≥3 g/dL) and a greater percentage of plasma cells in the bone marrow (≥10% and <60%), but no evidence of my...