Increased Bone Marrow Plasma Cell Infiltration Pre-Transplant Is Associated with Worse Outcomes in Patients Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation for Multiple MyelomaNina Shah, MD
In conclusion, elevated BM plasma levels of sCD30 reflected the enhanced CD30+ T cell-mediated immune response in SAA. CD30 as a molecular marker that transiently expresses on IFN-γ-producing T cells, may participate in mediating bone marrow failure in AA, which also can facilitate our ...
the presence of lysosomal storage disease was suggested by: a) the absence of malignancy, primary hematologic or liver disease, b) the presence of sea-blue histiocytes and vacuolation of macrophages and plasma cells in bone marrow smears, and c) an increase in plasma chitotriosidase activity....
Next, the plasma Ep level of mice injected with EB or SO for 2, 4, or 6 weeks was determined after exposure of the animals to hypoxia. Ep titers were greater than three times higher in EB mice than in SO mice, We conclude that at least two mechanisms act to cause the compensatory ...
Monoclonal gammopathy of undetermined significance (MGUS) is a relatively common abnormality in the older individuals, characterized by clonal proliferation of mature plasma cells in the bone marrow, with small numbers of these cells observed in the peripheral blood.1The prevalence is estimated to be ...
The presence of CD19 in myelomatous plasma cells (MM-PCs) correlates with adverse prognosis in multiple myeloma (MM). Although CD19 expression is upregulated by CD81, this marker has been poorly investigated and its prognostic value in MM remains unknown. We have analyzed CD81 expression by ...
Multiple myeloma (MM) is a B-cell malignancy characterized by the accumulation, primarily in bone marrow, of a clone of plasma cells. The nature of the stem cells feeding the tumoral compartment is still unknown. To investigate this spec... C Duperray,B Klein,BG Durie,... - 《Blood》 ...
Human myeloma cells were highly purified (more than 95%) from bone marrow aspirates in 14 cases of advanced multiple myelomas and one case of plasma cell leukaemia. Southern blotting revealed that a rearranged configuration of c-myc gene was found in only one case of them, but this was a...
Most patients with primary IgA nephropathy (IgAN) have a significantly higher memory repertoire of IgA1-producing B lymphocytes in their bone marrow together with high plasma levels of IgA1. The connection between the mucosal immune system and the bone marrow compartment is probably based on traffic...
Multiple myeloma (MM) is the second most frequent hematological malignancy as characterized by the clonal expansion of malignant plasma cells within bone marrow, affecting >30,000 individuals per year in the United States.1,2 In recent decades, many explorations and advances in therapeutics have pro...