“For example, our data shows that biopsies that draw marrow from just one type of bone may not provide a full picture of how the blood production system has been affected by a disease or other insult,” Lucas noted. “Meanwhile, efforts to stimulate production of certain blood ...
Production and turnover of blood cells are balanced so that numbers are maintained within normal ranges (steady-state kinetics) in healthy individuals. • Normally the bone marrow releases mostly mature cell types (and very low numbers of cells that are almost fully mature) into the circulation...
Equine blood and marrow has proven that transfer to human devices produces similar or greater cellular and growth factor concentrations than human blood. The great number of devices advertised for use on equine blood is in part due to this and in part due to the receptiveness of equine ...
found in red marrow, are responsible for the production of blood cells. Bone marrowmesenchymal stem cells(multipotent stromal cells) produce the non-blood cell components of marrow, including fat, cartilage, fibrous connective tissue (found in tendons...
These findings uncover a central role for MEF2C as a transcriptional activator of DNA repair and B-cell regulatory machinery in B-lymphoid progenitors, and establish that MEF2C-dependent transcriptional mechanisms are required to secure efficient bone marrow B-cell production during stress haematopoiesis...
Bone marrow cells In the foregoing mouse models ofrestenosis, the entire contents of the bone marrow were transplanted into the recipient mouse. Bone marrow is primarily composed of cells of theblood celllineages(e.g.myelocytes, lymphocytes,monocytes,megakaryocytes, erythrocytes) at various stages of...
By way of con- trast, stem cell-specific markers such as Nanog and Sox2 were expressed from the cells in the middle layer. Consequently, Percoll density gradient centrifugation eliminated fat and red blood cells in bone marrow and helped to isolate multipotent cells for subsequent procedures. The...
The bone marrow receives feedback from the flowing blood and controls the number of cells produced for a particular cell type. Overproduction of a particular cell type, especially that forced by disease, like leukemia, suppresses production of other cell types leading to corresponding symptoms.Bone ...
Stromal cells in myeloid and lymphoid long-term bone marrow cultures can support multiple hemopoietic lineages and modulate their production of hemopoietic growth factors. Blood. 1986;68:1348–54. CAS PubMed Google Scholar Schreml S, Babilas P, Fruth S, Orsó E, Schmitz G, Mueller MB, et ...
bone marrow-derived DCs and at lower levels on macrophages. DC-HIL acts as a negative regulator ofT cell activationwhere its putative ligand is expressed on activated but not on resting T cells (Figure 11.2). The binding of DC-HIL to its ligand potentially involves heparin sulfate as well ...