“For example, our data shows that biopsies that draw marrow from just one type of bone may not provide a full picture of how the blood production system has been affected by a disease or other insult,” Lucas noted. “Meanwhile, efforts to stimulate production of certain blood cell types ...
Production and turnover of blood cells are balanced so that numbers are maintained within normal ranges (steady-state kinetics) in healthy individuals. • Normally the bone marrow releases mostly mature cell types (and very low numbers of cells that are almost fully mature) into the circulation...
Abstract A hypothesis is proposed that the oscillations in blood cell numbers are the result of suppressed productivity of the bone marrow and its ability to satisfy both the demands of the erythroid and myeloid cell lines. The hypothesis is used as the basis for a mathematical model which ...
found in red marrow, are responsible for the production of blood cells. Bone marrowmesenchymal stem cells(multipotent stromal cells) produce the non-blood cell components of marrow, including fat, cartilage, fibrous connective tissue (found in tendons...
Bone marrow cells In the foregoing mouse models ofrestenosis, the entire contents of the bone marrow were transplanted into the recipient mouse. Bone marrow is primarily composed of cells of theblood celllineages(e.g.myelocytes, lymphocytes,monocytes,megakaryocytes, erythrocytes) at various stages of...
These findings uncover a central role for MEF2C as a transcriptional activator of DNA repair and B-cell regulatory machinery in B-lymphoid progenitors, and establish that MEF2C-dependent transcriptional mechanisms are required to secure efficient bone marrow B-cell production during stress haematopoiesis...
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood 2009; 114: 1331–1339. Article CAS PubMed PubMed Central Google Scholar Rankin SM . The bone marrow: a site of neutrophil clearance. J Leukoc Biol 2010; 88: ...
Understanding Bone Marrow Fibrosis This life-like architecture enabled the team to study how the cells in the bone marrow interact to support normal blood cell production, and how this is disturbed in bone marrow fibrosis (myelofibrosis), where scar tissue builds up in the bone marrow, causing ...
Cord blood stem cell transplantationBone marrow transplantationHepatitis-associated aplastic anemiaMyelodysplastic syndromeGrowth factorA 9-year-old girl who had hepatitis-associated aplastic anemia was treated intermittently with methylprednisolone pulse therapy and growth factors (granulocyte-colony stimulating ...
This can occur via a number of possible mechanisms: cell–cell interactions, the elaboration of known or novel osteogenic cytokines, and/or the production of osteoinductive ECM molecules. We thus sought to evaluate this limb of the bone–bone marrow coregulatory process by examining the possible ...