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Plasma cells, including a long-lived subset, reside in the bone marrow where they depend on poorly defined microenvironment-linked survival signals1. We show that bone marrow plasma cells use the ligand-gated purinergic ion channel P2RX4 to sense extracellular ATP released by bone marrow ...
HYPOCELLULAR BONE MARROW The marrow in severe aplastic anemia is markedly hypocellular with a profound decrease in hematopoietic tissue and a corresponding increase in marrow fat (Fig. 16.1). Macrophages containing hemosiderin are often prominent, and increased proportions of lymphocytes, plasma cells, ...
Lifetime of plasma cells in the bone marrow. Nature 1997; 388: 133–134. Article CAS PubMed Google Scholar Minges Wols HA, Underhill GH, Kansas GS, Witte PL . The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity. J Immunol 2002; 169: 4213–4221....
Human bone marrow plasma is the liquid component of blood. Bone marrow plasma consists of dissolved proteins, glucose, clotting agents, minerals, hormones, and carbon dioxide. It makes up approximately 55% of the whole bone marrow suspension. This whole bone marrow plasma is isolated from a sing...
The cover of this textbook bears an artist’s rendering of a tumor microenvironment in which tumor-associated macrophages (TAMs) have infiltrated among the cancer cells. TheseTAMsare derived from “myeloid-derived suppressor cells” (MDSCs), which are bone marrow-derived myeloid progenitors that ap...
(IMT) is a mass-forming lesion, included in a variety of non-neoplastic and neoplastic entities, billed by the generic term of inflammatory pseudotumor, sharing common histological features, characterized by spindle cell proliferation, with a varying infiltrate of plasma cells, lymphocytes, eosinophils...
A 37-year-old male patient with advanced refractory plasma cell myeloma underwent T-cell depleted bone marrow transplantation (BMT) after 7 years of active disease previously treated with combination chemotherapy and irradiation. After the BMT there was marked clinical improvement and the patient is ...
Diet-induced obesity promoted tumor growth in bone marrow and spleen Full size image At end point mice with diet-induced obesity (DIO) had a higher tumor load measured as circulating levels of M-component (Fig.1C) and percent plasma cells in the bone marrow compared with control mice (Fig...
Bone-marrow-derived macrophages in mammals are ubiquitously dispersed, mononucleated cells that have the capacity to fuse with each other to form specialized, multinucleated osteoclasts or giant cells. From: International Review of Cell and Molecular Biology, 2011 ...