This is a cancer of the plasma cells in bone marrow. Plasma cells are a type of white blood cell that makes antibodies. Myeloma cells spread through the bone marrow. They can damage your bones and crowd out healthy blood cells. These cells also make antibodies that can't fight off infecti...
bone marrow homingcancer-cell-biomimetictargeted therapyMultiple myeloma (MM) is the second most common hematological malignancy. It is characterized by abnormal transformation and uncontrolled clonal proliferation of malignant plasma cells in the bone marrow (BM), which can destroy bone structure and ...
Over the lifespan, skull bone marrow takes a more prominent role producing vital blood cells — plus how a radioactive lead isotope could help age the Solar System. Nick Petrić Howe &Elizabeth Gibney News|08 November 2024 This scientist treated her own cancer with viruses she grew in the ...
The evolution of CAR-T cell structure. There are five generations of CAR-T cells to date. scFv is currently the most commonly used targeting domain for CAR-T cells, and VHH is also emerging as a targeting domain for CAR-T cells with great potential. VH: heavy chain variable domain; VL:...
in tissue. Stromal cells consist of hematopoietic and meschenchymal stem cells. Hematopoietic stem cells are responsible for blood forming cells such as erythrocytes, plasma cells, T and B lymphocytes. Erythrocytes are responsible for formation of red blood cells and plasma cells are responsible for...
Circulating tumour-derived microvesicles in plasma of gastric cancer patients Cell membrane microfragments called microvesicles (MV) originating from different cells are circulating in the blood of healthy subjects and their elevated... J Baran,M Baj-Krzyworzeka,K Weglarczyk,... - 《Cancer Immunolo...
It is characterized by abnormal transformation and uncontrolled clonal proliferation of malignant plasma cells in the bone marrow (BM), which can destroy bone structure and inhibit hematopoiesis. Although there are new therapeutic methods, they are not curative, mainly because it is difficult to ...
(targets CD40, a co-stimulatory protein found in antigen-presenting cells), and (vii) Poly-ICLC (an immunostimulant)[5]. Targeted small molecule inhibitors in SCLC clinical trials include (i) sitravatinib, or MGCD516 (a multi-kinase inhibitor of PDGFR, VEGFR, and the Trk and Eph ...
Multiple myeloma is a form of cancer in which the plasma cells in the bone marrow grow out of control, causing damage to bones as well as predisposing patients to anaemia, infection and kidney failure. A medical procedure called autologous hematopoietic stem cell transplantation, commonly known as...
Tumour cells can find in bone marrow (BM) a niche rich in growth factors and cytokines that promote their self-renewal, proliferation and survival. In turn, tumour cells affect the homeostasis of the BM and bone, as well as the balance among haematopoiesis, osteogenesis, osteoclastogenesis and ...