单位:复旦大学附属中山医院检验科 2024年1月18日,复旦中山检验科最新研究成果《Detection of Circulating Plasma Cells in Peripheral Blood Using Deep Learning-Based Morphological Analysis》在国际权威杂志Cancer(IF=6.2,JCR Q1区,Doi:10.100...
We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural survival and antitumour activity of GPC3 (expressed in a group of solid cancers) CAR T cells....
肿瘤浸润的B细胞和浆细胞(Tumor-infiltrating B and plasma cells (TIBs))能够影响化疗和免疫治疗的反应及预后【1,2】,但已有的单细胞研究缺乏对TIBs在实体肿瘤发病机制中表型和状态的深入解析。 2022年9月13日,德克萨斯大学MD安德森癌...
「B cells/plasma cells亚类」:CD20+ B cell (sc-b0, sc-b2),7 SDC1+ (CD138) plasma cell clusters (Figures 3A and 3B) 「T/NK-cells」:8个subclusters, sc-t1和 sc-t7:NK-like cells,marker为NKG7,KLRB1 sc-t2:naive CD4+ /CD8+ T cells sc-t3:Tregs sc-t5:follicular-helper T cells ...
Cancer metabolism refers to the alterations in cellular metabolism pathways that are evident in cancer cells compared with most normal tissue cells. Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation and the increased generation of biosynthetic...
2022年9月13日,美国德克萨斯大学的王玲华博士等人在《Cancer Discovery》上发表了一篇“The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma”的文章,文章对16个早期LUADs和47个匹配的多区域正常组织进行配对的单细胞RNA和B细胞受体(BCR)测序。通过对约5万个TIBs的综合...
It is the main lymphoid organ, where all the lymphocytes and all the body cells are produced and T-lymphocytes are developed. (b) Thymus It is a lobed organ, located near the heart and beneath the breast bone. It is large at the time of birth but with age, the size keep on reducing...
Contact Interactions Between Cells That Suppress Neoplastic Development: Can They Also Explain Metastatic Dormancy? A case of cancer in which cells similar to those in the tumors were seen in the blood after death. Aust Med J 1869;14:146... H Rubin - 《Advances in Cancer Research》 被引量...
Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy to investigate the consequences of chromosomal imbalance, identifying CRAF as an aneuploid-sele...
. We also found increasing quantities of plasma cells had a continuous positive association with both increasing inflammation andIFNGexpression while CD8+T-cells, the immune cells more commonly thought to mediate the most tumor immune activity11, did not (Fig.1g). In the setting of increased ...