The RNA-binding protein LARP6 regulates the alternative splicing of related genes in MDA-MB-231 cells Li Guo ,Yaobang Liu &Jinping Li Article 06 March 2025|Open Access Assessing oral Health-Related quality of life in women undergoing chemotherapy for breast Cancer in Karachi Pakistan ...
Deciphering response dynamics and treatment resistance from circulating tumor DNA after CAR T-cells in multiple myeloma Circulating tumor DNA (ctDNA) allows genotyping of the tumor in multiple myeloma. Here, the authors show that minimal residual disease (MRD) by ctDNA can be detected after CAR-...
Wang是该团队在《Cancer Discovery》上发表的论文的共同通讯作者,该论文题为“The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma”。在他们的报告中,作者总结道:“这项研究提供了对TIB的转录、克隆型状态和表型的急需理解,揭示了它们在早期LUAD免疫病理学中的潜在作用...
2022年9月13日,美国德克萨斯大学的王玲华博士等人在《Cancer Discovery》上发表了一篇“The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma”的文章,文章对16个早期LUADs和47个匹配的多区域正常组织进行配对的单细胞RNA和B细胞受体(BCR)测序。通过对约5万个TIBs的综合...
应用合理的早期治疗方案需要对肿瘤免疫微环境有深入的理解。肿瘤浸润的B细胞和浆细胞(Tumor-infiltrating B and plasma cells (TIBs))能够影响化疗和免疫治疗的反应及预后【1,2】,但已有的单细胞研究缺乏对TIBs在实体肿瘤发病机制中表型...
Cells in the body differ from each other to maintain the proper functioning of the tissues and organs, which they build. The lipid profile of the plasma membrane is a distinctive cell property and might be considered as characteristic for a specific cell type (Pradas 2018). Alterations arise ...
Cells can also oxidize other substrates like amino acids and fatty acids obtained from either the environment or the degradation of cellular macromolecules. As a result, the majority of ATP (yellow stars) is generated by oxidative phosphorylation. During proliferation (right), the large increase in...
Exosomes derived from tumor cells contribute to the pathogenesis of cancers. Metformin, the most usually used drug for type 2 diabetes, has been frequently investigated for anticancer effects. Here, we examined whether metformin affects exosomes signalin
Among non-epithelial cells, PYCR1 was expressed in plasma cells and CAFs, particularly in a subset of myCAFs that express higher levels of COL1A1 (Fig. 2f,g and Extended Data Fig. 2a,b). In contrast, PYCR2 was expressed by few CAFs (Extended Data Fig. 2c), in line with our in ...
Overall, 301,662 cells were included in the training reference dataset of scATOMIC. Obtaining an accurate set of differentiating features is critical to successful classification. Nonetheless, significant differentially expressed genes (DEG) concerning non-malignant cell types are often expressed in other...