Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate their strict control by the tumor genotype: in isocitrate dehydrogenase (IDH)-mutant tumors, differentiation of infiltrating myeloid cells is blocked, resulting in an immature phenotype. In late-stage...
A population-based study on incidence trends of myeloma in the United States over 2000–2020 3 morphological codes 9731, 9732, and 9734 were assigned for solitary plasmacytoma of bone, plasma cell myeloma, and extraosseous plasmacytoma, respectively... SE Mousavi,M Ilaghi,A Aslani,... - 《S...
Plasma levels of sex hormones and Sex Hormone Binding Globulin (SHBG) were measured by immunometry. 20 samples were excluded, leaving 425 hormone measurements. Results 20% of postmenopausal women were HRT users. The plasma levels of estradiol (E2) increased with an increased E2 dose, and use ...
000 infected) and many deaths (>25,000) resulting from COVID-19, particularly older people with chronic diseases (including cardiovascular and diabetes) and cancer. COVID-19 highlighted the weakness of health systems in several locations,
Growing concern has arisen from the quasi-exponential increase in the numbers and quantities of man-made chemicals that presently are in current use, and their potential effects on human health, especially their delayed effects on degenerative diseases s
The tumour-derived monoclonal IgM antibody PAT-SM6 specifically kills malignant cells by an apoptotic mechanism linked to the excessive uptake of plasma lipids. The mechanism is postulated to occur via the multi-point attachment of PAT-SM6 to the unfolded protein response regulator GRP78, located ...
Among non-epithelial cells, PYCR1 was expressed in plasma cells and CAFs, particularly in a subset of myCAFs that express higher levels of COL1A1 (Fig. 2f,g and Extended Data Fig. 2a,b). In contrast, PYCR2 was expressed by few CAFs (Extended Data Fig. 2c), in line with our in ...
Cells in the body differ from each other to maintain the proper functioning of the tissues and organs, which they build. The lipid profile of the plasma membrane is a distinctive cell property and might be considered as characteristic for a specific cell type (Pradas 2018). Alterations arise ...
Breast cancer is the most common malignancy among women globally. Development of a reliable plasma biomarker panel might serve as a non-invasive and cost-effective means for population-based screening of the disease. Transcriptomic profiling of breast tu
Fig. 1: The major signaling pathways in ferroptosis. The GPX4-GSH pathway occurs mainly in the cytoplasm (cGPX4) and mitochondria (mGPX4). This axis can be inhibited by FINs and tumor suppressor p53. The FSP1-CoQ pathway occurs in the plasma membrane which can be inhibited by iFSP. The...