Lifetime of plasma cells in the bone marrow Nature, 388 (1997), pp. 133-134 Google Scholar 16. M.K. Slifka, R. Antia, J.K. Whitmire, R. Ahmed Humoral immunity due to long-lived plasma cells Immunity, 8 (1998), pp. 363-372 View PDFView articleView in ScopusGoogle Scholar 17. ...
Radbruch A (2002) Plasma cells for a lifetime - RA () Citation Context ...ting from the lymphoid organs to the become long-lived PC in the bone marrow (LLPC), or they could be pre-existing LLPC that have been dislodged from their bone marrow niche by the newly migrating PC =-=[...
Here we discuss recent evidence suggesting, why current protocols for the treatment of IgE-mediated allergies fail: Memory plasma cells generated by inhalation of the allergen become long-lived and are maintained preferentially in the bone marrow. They do not proliferate, and are refractory to ...
Molecular oxygen (O2) is essential for cellular function and is continuously supplied to whole tissues in the body to maintain homeostasis. Oxygen deprivation (hypoxia) in tissues is associated with the pathophysiology of various diseases such as cerebral infarction, fatty liver disease, chronic kidney...
Next, heparinized tubes were centrifuged for 10 min at 4 °C and 4200 g to pellet the blood cells for the collection of plasma. Plasma from the heparinized blood samples were used in part for the immunoglobulin and plasma biomarker measurements. Another fraction was used for clinical ...
Throughout, the AKR/O strain has higher levels of plasma ESF and bone marrow CFU-E concentrations than the WLO strain, indicating both a reduced Epo responsiveness and some degree of ineffective erythropoiesis in the AKR/O strain. At all ages the AKR/O strain has a high concentration of ...
The age-associated decline in immune function, referred to as immunosenescence, is well characterised within the adaptive immune system, and in particular, among T cells. Hallmarks of immunosenescence measured in the T cell pool, include low numbers and proportions of naïve cells, high numbers an...