在单药应用帕博利珠单抗后有12例患者出现应答,且12例患者均为PD-L1阳性患者,客观缓解率(objective response rate,ORR)为14.6%,疾病控制率(disease control rate, DCR)达到32.9%。基于上述试验结果,2018年6月12日,美国食品药品监督管理局(Food and Drug Administration,FDA...
High PD-1 expression group had lower (P=0.019) 5-year overall survival rate than low PD-1 expression group. Multivariate analysis revealed that PD-1 was an independent prognostic factor for cHL with significance (P=0.026). However, PD-L1, PD-L2, and VEGF expression had no prognostic ...
rate (DCR), and duration of response (DOR) assessed by investigators. Secondary objectives are to evaluate the safety of HLX301 and to investigate the association between PD-L1 expression levels and the antitumour acti...
Importantly, using a mouse model of concanavalin A (ConA)-induced autoimmune hepatitis, we revealed that WJ-MSCs with high expression of PD-L1 (PD-L1high WJ-MSCs) produced better therapeutic efficacy and stronger immunosuppression compared to PD-L1low WJ-MSCs by altering T subset proliferation ...
3.Yarchoan Mark,Albacker Lee A,Hopkins Alexander C et al. PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.[J] .JCI Insight, 2019, 4: undefined. 4.Brahmer JR, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory...
3.Yarchoan Mark,Albacker Lee A,Hopkins Alexander C et al. PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.[J] .JCI Insight, 2019, 4: undefined. 4.Brahmer JR, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory...
中文摘要: 目的:从我国卫生体系角度评价帕博利珠单抗对比一线化疗方案治疗程序性细胞死亡蛋白配体1(PD-L1)高表达的晚期非小细胞肺癌的经济性。方法:利用已发表的KEYNOTE-042临床试验数据和相关文献数据建立马尔可夫模型,评价帕博利珠单抗对比一线化疗方案的经济性;模拟时限为20年,周期为3周,对成本和效用采用5%的贴现率进...
This study was conducted to explore programmed cell death‐ligand‐1 (PD‐L1) expression and fibroblast growth factor receptor 1 (FGFR1) amplification in stageIIIB/IVlung squamous cell carcinoma (SQC). Correlations betweenPD‐L1 andFGFR1, and with clinicopathological characteristics, efficacy of platin...
tissue of positive expression rate was higher than the organization and the normal tissue cancer. PD-L1 molecule is a new promising biomarker for prevention, diagnosis and prognosis of liver cancer. It suggested that PD-L1 is a new target for liver cancer ...
Pearson correlation test was used to analyze the correlation between PD-L1 and TS at protein expression level and mRNA expression level.Results: Among 51 patients with advanced lung adenocarcinoma who received pemetrexed-base...