PD-L1 expression in both TCs and ICs was more frequent in POLE ultramutated and MMR-deficient subtypes than in p53-mutant and NSMP subtypes. PD-L1 positivity in TCs, but not in ICs or combined (CPS), was associated with a favorable prognosis in patients with high-risk endometrial cancer....
非小细胞肺癌肿瘤细胞中 PD-L1 表达对病理学家的挑战-概述 The Challenge to the Pathologist of PD-L1 Expression in Tumor Cells of Non-Small-Cell Lung Cancer-An Overview 上下滑动查看 近年来,应用抗程序性死亡蛋白 1 ...
斯坦福大学医学院科学家Weissman和同事的题为《PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity》的研究表明,PD-1/PD-L1抗体可通过促使巨噬细胞吞噬癌细胞抗击癌症。该研究结果被发表于2017年的《自然》杂志。 Wei...
题为”PD-L1 expression on circulating tumor cells can be a predictive biomarker to PD-1 inhibitors combined with radiotherapy and antiangiogenic therapy in advanced hepatocellular carcinoma”(循环肿瘤细胞上PD-L1的表达可作为PD-1抑制剂联合放射治疗和抗血管生成治疗晚期肝细胞癌的预测生物标志物),旨在确定程...
近日,江南大学附属医院肿瘤研究所黄朝晖团队联合复旦大学附属肿瘤医院黄胜林课题组,在国际知名学术期刊 Advanced Science 杂志发表了题为“Colorectal cancer-derived small extracellular vesicles promote tumor immune evasion by upregulating PD-L1 expression in tumor-associated macrophages”的论文,阐明了结直肠癌来源的细...
■研究题目:Prognostic relevance of PD-L1 expression on circulating tumor cells in metastatic breast cancer patients treated with anti-PD-1 immunotherapy ■海报编号:P5-02-12 ■公布时间:12月08日5:00 pm-6:15 pm CT 研究背景:循环肿瘤细胞(CTCs)的检测越来越有前途,因为它是一种微创、可重复、经济有...
PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients. Sci. Rep. 2016, 6, 36956. [CrossRef] [PubMed]Kim HR, Ha SJ, Hong MH, Heo SJ, Koh YW, Choi EC, et al. PD-L1 expression on immune cells, but not on...
SunLL, YangRY, LiCW, et al.Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing[J].Am J Cancer Res, 2018, 8(7): 1307-1316. SatoH, NiimiA, YasuharaT, et al.DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells[J]...
Janning M, Kobus F, Babayan A, et al. Determination of PD-L1 Expression in Circulating Tumor Cells of NSCLC Patients and Correlation with Response to PD-1/PD-L1 Inhibitors [J] Cancers, 2019, 11, 835. Klaus Pantel 被国际同行称为“液体活检之父”,是该领域的主要开创者之一、也是“液体活检...
Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with radiation. However this has not been validated in patients with non-small cell lung cancer due to the difficulty to obtain serial biopsies. ...