医学评论英文版原文:Tone M, Iwahori K. PD-1 expression on tumor cells: a new target for cancer therapy. Transl Lung Cancer Res 2024;13(1):186-189. doi: 10.21037/tlcr-23-683 被点评研究:Rotolo R, Leuci V, Donini C, et al. Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocki...
文献速递 2022年8月,西南医科大学附属医院肿瘤科Ke Su教授及其团队在《Frontiers》杂志上发表研究,题为”PD-L1 expression on circulating tumor cells can be a predictive biomarker to PD-1 inhibitors combined with radiotherapy and antiangiogenic therapy in advanced hepatocellular carcinoma”(循环肿瘤细胞上PD-L...
Although immune checkpoint inhibitors targeting programmed death-1 (PD-1) are promising, it remains unclear whether PD-L1 expression on circulating tumor cells (CTCs) has predictive and prognostic values in predicting and stratifying metastatic breast cancer (MBC) patients who can benefit from anti-...
2.Kumagai, S. et al. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell 0, (2022). 3. Schmidl, C., Hansmann, L., Blood, T. L.-, Journal, T. & 2014, undefined...
PD-1, programmed death-1; PD-L1, programmed death-ligand 1; DLBCL, diffuse large B-cell lymphoma; PAX5, paired box 5; TME, tumor microenvironment. Table 2. Expression of PD-1 and PD-L1 in patients with de novo DLBCL. 2.3. Correlation between PD-1 Expression on Lymphoma Cells and ...
Enhanced PD-L1 expression on tumor cells in primary CD30-positive cutaneous large T-cell lymphoma: a report of lymph node lesions of four cases Scarce data are available regarding neoplastic PD-L1 (nPD-L1, clone SP142) expression in cutaneous T-cell lymphoma. We recently documented a possible...
(PD-L1) expression on tumor cells can render human CAR T cells (anti-CD19 4-1BBζ) hypo-functional, resulting in impaired tumor clearance in a sub-cutaneous xenograft model. To overcome this suppressed anti-tumor response, we developed a protocol for combined Cas9 ribonucleoprotein (Cas9 RNP...
Intrinsic and extrinsic effects of PD-L1 expression on tumor cells. a PD-L1 can bind to PD-1 expressed on immune effector cells. This interaction induces T-cell apoptosis, T-cell exhaustion, selective suppression of tumor-specific T-cells (“molecular shield” effect) and regulatory T cells....
In contrast to normal tissues, which show minimal surface expression of PD-L1 protein, PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. ...
[13] Y Iwai et al., (2002), Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade, PNAS, DOI:https://doi.org/10.1073/pnas.192461099 [14] Five-year follow-upfrom the CA209-003 study of nivolumab in previously treated adva...