PD-1 expression on tumor cells: a new target for cancer therapydoi:10.21037/tlcr-23-683Anti programmed death-1 antibody (anti-PD-1 antibody)cancer stemnessnon-small cell lung cancer (NSCLC)chemoresistanceMari ToneKota IwahoriTranslational Lung Cancer Research...
文献速递 2022年8月,西南医科大学附属医院肿瘤科Ke Su教授及其团队在《Frontiers》杂志上发表研究,题为”PD-L1 expression on circulating tumor cells can be a predictive biomarker to PD-1 inhibitors combined with radiotherapy and antiangiogenic therapy in advanced hepatocellular carcinoma”(循环肿瘤细胞上PD-L...
2.Kumagai, S. et al. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell 0, (2022). 3. Schmidl, C., Hansmann, L., Blood, T. L.-, Journal, T. & 2014, undefined...
In this study we tested whether Cas9 RNP mediated disruption of the endogenousPdcd1locus in primary human CAR T cells enhances anti-tumor efficacy. We found that PD-L1 expression on tumor cells impaired CAR T cell mediated killingin vitroand tumor clearancein vivoin a xenograft model. These de...
2024年8月8日,Cell杂志背靠背在线发表美国匹兹堡大学医学院Dario A.A. Vignali研究团队题为LAG-3 and PD-1 synergize on CD8+T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity和Bl...
[13] Y Iwai et al., (2002), Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade, PNAS, DOI:https://doi.org/10.1073/pnas.192461099 [14] Five-year follow-upfrom the CA209-003 study of nivolumab in previously treated adva...
Interestingly, nPD-L1 was expressed on more than 50% of the tumor cells in the secondary nodal lesions, but on very few in the primary cutaneous lesions, in both cases. This is the first report of nPD-L1 expression greatly increasing with PCLTCL tumor progression to nodal involvement. 展开...
Little is known about prevalence of PD-L1 expression in tumor cells of unselected patients with all stages of non-small cell lung cancer. The objective of this study is to assess the prevalence of PD-L1 positivity in patients with non-small cell lung can
Intrinsic and extrinsic effects of PD-L1 expression on tumor cells. a PD-L1 can bind to PD-1 expressed on immune effector cells. This interaction induces T-cell apoptosis, T-cell exhaustion, selective suppression of tumor-specific T-cells (“molecular shield” effect) and regulatory T cells....
基于以上模型,我们可以大胆假设,那些没有T细胞浸润的cold tumor,可能在以上事件中的哪一步出现了障碍或差错。也许有人会argue抗原性低是导致cold tumor无T细胞浸润的主因。对于这一点,有文献报道,冷肿瘤和热肿瘤在抗原数量上非常相似,至少没有我们想象中那样大。所以冷肿瘤中抗原性低的推断可能不是或者至少不是主要...