医学评论英文版原文:Tone M, Iwahori K. PD-1 expression on tumor cells: a new target for cancer therapy. Transl Lung Cancer Res 2024;13(1):186-189. doi: 10.21037/tlcr-23-683 被点评研究:Rotolo R, Leuci V, Donini C, et al. Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocki...
Circulating tumor cellsBackground: PD-1 inhibitors are routinely used for the treatment of advanced melanoma. This study sought to determine whether PD-L1 expression on circulating tumor cells (CTCs) can serve as a predictive biomarker of clinical benefit and response to treatment with the PD-1 ...
文献速递 2022年8月,西南医科大学附属医院肿瘤科Ke Su教授及其团队在《Frontiers》杂志上发表研究,题为”PD-L1 expression on circulating tumor cells can be a predictive biomarker to PD-1 inhibitors combined with radiotherapy and antiangiogenic therapy in advanced hepatocellular carcinoma”(循环肿瘤细胞上PD-L...
Here, total phagocytosis was analysed by first gating on TAMs, and then gating on YFP+ cells. Total TAM PD-1 expression from the same tumour sample is shown side by side to demonstrate that high PD-1 expression inversely correlates with phagocytosis. b, Analysis of PD-1− TAM phagocytosis...
Programmed death ligand 1 (PD-L1) found on tumor cells has recently been reported to have a key role in the development and dissemination of many tumors, such as lung and breast carcinomas. In this study, we retrospectively analyzed PD-L1 expression among different types of sarcomas.Tissue mi...
In contrast to normal tissues, which show minimal surface expression of PD-L1 protein, PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. ...
2.Kumagai, S. et al. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell 0, (2022). 3. Schmidl, C., Hansmann, L., Blood, T. L.-, Journal, T. & 2014, undefined...
While PD-1 expression on tumor-infiltrating lymphocytes has been associated with poor outcome in RCC, we sought to define immune cell biomarkers, including PD-1, on peripheral blood mononuclear cells (PBMC) that could predict disease progression of RCC patients before and after nephrectomy. We ...
[13] Y Iwai et al., (2002), Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade, PNAS, DOI:https://doi.org/10.1073/pnas.192461099 [14] Five-year follow-upfrom the CA209-003 study of nivolumab in previously treated adva...
The Prognostic Value of PD-1/PD-L1 Expression on Tumor Cells and Tumor-Infiltrating Immune Cells in Patients with Colorectal Cancer: a Systematic Review an... However, the role of immune checkpoint molecules, especially Programmed cell death protein 1 (PD-1) and Programmed cell death-ligand 1...