Checkpoint ligand expression in non-tumoral cells of tissues affected by immune-related adverse effects has been described in ICI-associated hypophysitis, myocarditis, and acute interstitial nephritis. We aimed to investigate the tissue expression of the immune checkpoint receptor programmed cell death-1 ...
RESULTS PD-L1 Expression Patterns, Prevalence, and Expression Levels PD-L1 tumor cell expression was observed in 30% (60/200) of specimens studied. When present, PD-L1 expression on tumor cells was predominantly observed in geographic association with CD8+ T-lymphocytes, consistent with an ...
PD-L1 expression on circulating tumor cells (CTCs) could aid in screening and monitoring patients16. CTCs are tumor cells that are shed from various locations of the primary and/or metastatic tumors17,18,19. As such, they may represent a greater portion...
(Middle right) The fraction of cells in each cluster from metastatic lymph node (mLN), non-metastatic lymph node (nLN), normal adjacent lung tissue (nLung), tumor biopsy (Tbio), and tumor resection (T res) is shown. (Bottom) Relative average expression of indicated markers in clusters ...
[12] Faraj SF, Munari E, Guner G, et al. Assessment of tumoral PD- L1 expression and intratumoral CD8 + T cells in urothelial carcinoma[J]. Urology, 2015, 85(3): 703.e1-6. DOI:10.1016/j.urology.2014.10.020...
Further, THZ1 suppressed PD-L1 expression by inhibiting MYC activity. THZ1 boosted antitumor immunity by recruiting infiltrating CD8+ T cells and synergized with antiPD-1 therapy. The CDK7/MYC/PD-L1 signature and infiltrating T cell status collectively stratified NSCLC patients into different risk ...
PD-1 expression is upregulated in activated T cells, whereas its dominant ligand PD-L1 is primarily expressed on tumor cells following exposure to pro-inflammatory cytokines in the tumor microenvironment, resulting in adaptive immune resistance [6, 8]. High PD-L1 expression in patients with NSCLC...
The study on non-small cell lung cancer (NSCLC) cells showed a positive correlation between IL-6 expression and PD-L1 expression alongside the infiltration of myeloid-derived suppressor cells (MDSCs), M2 macrophages, and Tregs, highlighting its critical role in the suppression of immune response ...
also found that PD-L1 expression could be regulated by INF-γ in GC15. However, the specific molecular mechanism for regulating PD-L1 expression in GC cells remains unclear. Mesenchymal stem cells (MSCs) with multiple differ- entiation potential and immune modulating function, are one of the ...
cells. Here, we show that exosomes derived from lung cancer cells express PD-L1 and play a role in immune escape by reducing T-cell activity and promoting tumor growth. The abundance of PD-L1 on exosomes represented the quantity of PD-L1 expression on cell surfaces. Exosomes containing PD-...