PD-L1 immunohistochemistry in lung cancer: in what state is this art? J Thorac Oncol 2015;10:985-9.K.M. Kerr, M.-S. Tsao, A.G. Nicholson, et al., PD-L1 immunohistochemistry in lung cancer: in what state is this art? J. Thorac. Oncol. 10 (2015) 985-989....
Mesothelioma Cancer– The interaction of PD-1 and PD-L1 proteins can prevent T cells from killing mesothelioma cancer cells. Keytruda (pembrolizumab), an anti-PD-1/PD-L1 drug, has been successful in inhibiting communications between these types of cells and t...
Prognosis, diagnosis, or who knows? Time to learn what gene tests mean 来自 国家科技图书文献中心 喜欢 0 阅读量: 14 作者: P Cotton 摘要: THE MUCH-HERALDED genetics revolution in medicine, though still largely limited to academe, is lurching relentlessly toward the primary care physician's ...
The understanding of the regulation of T-cell activation and function along with the discovery of immune checkpoints with respect to the CD28 and B7 family has led to major advances scientifically and therapeutically in cancer. Clinical trials of agents targeting the PD-L1 checkpoint pathway have ...
I emphasize that we should not doubt the results of phase III trials that have proven clinical utility – but just because an assay is theoretically useful does not mean it is practically so. If we don’t act now, the problems we currently have with PD-L1 testing will spread to gene ...
PD-L1 was expressed by immune or stromal cells in 12% and 69% cases, respectively. Tumor heterogeneity, inter-institutional preanalytics, and inter-observer interpretation variability may account for result biases. Keywords: PD-L1; prostate; cancer; adenocarcinoma; immunohistochemistry; target-therapy;...
The aim of this review is to present the interest in using cytological and/or liquid biopsies as complementary biological material, or as an alternative to tissue specimens, for detection at diagnosis of new predictive biomarkers of NS-NSCLC. Keywords: lung cancer; biomarkers; cytology; liquid ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook AcronymDefinition MHLWMinistry of Health, Labor and Welfare(Japan; formerly Ministry of Health and Welfare, MHW) MHLWMean High Low Water(tide level) Copyright 1988-2018AcronymFinder.com, All rights reserved. ...
the immune response is dynamic and PD-L1 expression at a single time point may not reflect an evolving immune response in the blood or tumor microenvironment, pre-surgical and tissue-abased clinical trials provide a feasible immune monitoring platform to study biologic eff...
Both the CPS (r=0.775; P<0.001) and the IC score (r=0.711; P<0.001) correlated between primary and metastatic bladder cancer tissue. Employing CPS vs. IC led to significantly more PD-L1-positive classified cases in primary BC (CPS vs. IC; 43.5% vs. 28.7%; P<0.001) and lymph node...