5. Cytology cell blocks from malignant pleural effusion are good candidates for PD-L1 detection in advanced NSCLC compared with matched histology samples 6. Circulating Tumor Cell PD‐L1 Expression as Biomarker for Therapeutic Efficacy of Immune Checkpoint Inhi...
19. Shin J, Chung J-H, Kim SH, et al. Effect of platinum-based chemotherapy on PD-L1 expression on tumor cells in non-small cell lung cancer. Cancer Res Treat. 2019;51(3):1086-1097. 20. Rimm DL, Han G, Taube JM, et al. A prospective, multi-institutional, pathologist-based asse...
PD-L1 expression on tumor cells as a potential predictive biomarker for patients with unresectable stage III non-small cell lung cancer treated with chemoradiotherapy followed by durvalumabdoi:10.21037/tcr-23-52Non-small cell lung cancer (NSCLC)...
参考文献: 1.Effectsof Tumor-Derived Exosome Programmed Death Ligand 1 on Tumor Immunity andClinical Applications. Front Cell Dev Biol. 2021; 9: 760211. 公众号已建立“小药-生物资源对接服务平台”微信行业交流群以及读者交流群,扫描下方小编二维码加入,入行业群请主动告...
ZhangQ, LianK．Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion[J]．Cancer Cell Int，2020，20: 247.DOI: 10.1186/s12935-020-01310-y.ParsaAT, WaldronJS, PannerA, et al.Loss of tumor sup...
Oncol. 2020;21(2):283-293. doi:10.1016/S1470-2045(19)30797-1 16. Wang Z, Aguilar EG, Luna JI, et al. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019;25(1):141-151. doi:10.1038/s41591-018-0221-5 ...
此外,外泌体PD-L1有助于预测抗PD-L1/PD-1治疗的效果。然而,肿瘤源性外泌体PD-L1的研究还有很多未知,在临床实践中的应用还有很多工作要做。 参考文献: 1.Effectsof Tumor-Derived Exosome Programmed Death Ligand 1 on Tumor Immunity andClinical Applications. Front Cell Dev Biol. 2021; 9: 760211....
上的“Antigen cross-presentation in young tumor-bearing hosts promotes CD8+ T cell terminal differentiation”等。 PD-1/PD-L1与免疫衰竭的关系随着年龄的增长,免疫系统会经历渐进性的功能重塑,了解年龄如何影响抗肿瘤免疫对于设计有效的免疫疗法是至关重要的,尤其是对儿童患者而言。
3月11日,中南大学陈翔教授、刘洪教授、刘静教授团队联合在国际知名权威期刊Nature Genetics(IF=31.7)上在线发表了题为“Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma”的最新研究成果,首次揭示了琥珀酰化修饰是PD-L1降解的重要“分子开关”,进而影响肿瘤免疫。
Collectively, we demonstrate that PD-L1+ T cells have diverse tolerogenic effects on tumor immunity. 参考译文:程序性细胞死亡蛋白1(PD-1)限制了T细胞的免疫原性应答。但是,在T细胞中程序性细胞死亡1配体1(PD-L1)结合的后果尚不确定。我们发现,PD-L1在癌症中的T细胞表达受肿瘤抗原和无菌炎症因素的调节。PD-...