During the re-epithelialisation stage of wound healing, a partial epithelial-mesenchymal transition (pEMT) occurs in wound-edge keratinocytes. Here, sedentary and firmly cohesive keratinocytes respond to injury by reducing their interconnections and initiating migration over the wound bed to bring about...
partial epithelial mesenchymal transitionprognosisIncreasing evidence has revealed that cancer cells undergoing an intermediate state, partial epithelial mesenchymal transition (p〦MT), tend to metastasize rather than complete EMT. We performed a comprehensive analysis of Eヽadherin and 25 p〦MT‐related ...
The epithelial–mesenchymal transition (EMT) plays a crucial role in the differentiation of many tissues and organs. So far, an EMT was not detected in the development of the auditory organ. To determine whether an EMT may play a role in the morphogenesis of the auditory organ, we studied ...
During renal fibrosis, epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease. Progressive kidney fibrosis contributes greatly to end-stage renal failure, and no specific treatment is a
As our understanding of Epithelial Mesenchymal Transition (EMT) increases, the original binary concept of E versus M no longer fits with experimental evidence. Re-definition of the EMT paradigm as spectral transitions between a full epithelium and a full
Using rat and cellular models of CAG, we found that the JAK/STAT pathway is activated alongside partial epithelial-mesenchymal transition (pEMT). YQHYJD treatment effectively mitigated the activation of the JAK2/STAT3 activation and pEMT. Furthermore, the therapeutic effect of the YQHYJD formula ...
Our understanding of epithelial-to-mesenchymal transition (EMT) has slowly evolved from a simple two state, binary model to a multi-step, dynamic continuum of epithelial-to-mesenchymal plasticity, with metastable intermediate transition states that may drive cancer metastasis. Head and neck cancer is...
Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT also confers properties such as stemness, drug resistance and immune evasion which can aid a successful colonization at the dista...
Johnen N, Francart ME, Thelen N, Cloes M and Thiry M: Evidence for a partial epithelial‑mesenchymal transition in postnatal stages of rat auditory organ morphogenesis. Histochem Cell Biol 138: 477‑488, 2012.Johnen N, Francart M-E, Thelen N, Cloes M, Thiry M. Evidence for a ...
Epithelial–mesenchymal transition (EMT) plays a pivotal role for tumor progression. Recent studies have revealed the existence of distinct intermediate states in EMT (partial EMT); however, the mechanisms underlying partial EMT are not fully understood. Here, we demonstrate that αvβ3 integrin indu...