Epithelial-mesenchymal transition (EMT) is involved in physiologic processes such as embryogenesis and wound healing. A similar mechanism occurs in some tumors where cells leave the epithelial layer and gain mesenchymal particularities in order to easily migrate to other tissues. This proc...
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial–mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation ...
biomarkers, cancer, epithelial-mesenchymal-transition, metastasis From transformation to transition Our body is formed by cells of different types and functions. In this review, we will approach a phenomenon that occurs between two specific types, epithelial and mesenchymal. Epithelial cells are highly ...
(for instance, during metastatic spread of cancer). In all cases, the process is initiated when epithelial cells transition to become more mesenchymal-like or spindle-like cell, and endure a progressive loss of epithelial markers in parallel with a progressive gain of mesenchymal markers. ...
Gastric cancer cells with fibroblastoid morphological changes show increased motility and invasiveness due to decreased cell-cell adhesion, which are reminiscent of epithelial-mesenchymal transition (EMT) during embryonic development. Here, EMT signaling networks in gastric cancer were reviewed. E-cadherin ...
Bracken and Goodall discuss why epithelial–mesenchymal transition (EMT) has so many regulators, but also consider whether many of these may be ‘false positives’. Cameron P. Bracken Gregory J. Goodall Comments & Opinion09 Dec 2021Nature Reviews Molecular Cell Biology ...
“Epithelial-to-mesenchymal transition” (EMT) is a reversible, dynamic cellular program during which either healthy or neoplastic epithelial cells transform into a more motile, invasive, and aggressive mesenchymal cell type. From:Cancer Letters,2019 ...
EPLIN downregulation promotes epithelial–mesenchymal transition in 热度: Epithelial mesenchymal transition and cancer stem cells 热度: Epithelial-Mesenchymal Transition (EMT) - Cell Signaling … 热度: 相关推荐 © TheRockefellerUniversityPress,0021-9525/2000/01/173/15$5.00 TheJournalofCellBiology,...
上皮细胞间质转型（epithelial-mesenchymal transitions,EMT）是具有极性的上皮细胞转换成为具有活动能力的间质细胞并获得侵袭和迁移能力的过程,它存在于人体多个生理和病理过程中。EMT的发生涉及到多个信号转导通路和复杂的分子机制,与钙连接素、生长因子、转录因子、微环境等有关。EMT与肿瘤细胞的侵袭和转移...
Over the past two decades, the concept of the epithelial to mesenchymal transition (EMT) has been imported from embryology and oncology to fibrosis, particularly in the kidney. This interest in EMT in the context of renal fibrosis stems from observations