Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell 2004;7(3):425-38.Nakaya Y, Kuroda S, Katagiri YT, Kaibuchi K, Takahashi Y (2004) Mesenchymal-epithelial transition during somitic seg- mentation is regulated by ...
正如此前提到,外显子14在正常生理状态下,对于诱导c-Met降解并下调c-Met通路信号至关重要,外显子14的缺失正是c-Met通路过度活化的重要原因。HLX55的临床前数据显示,即使是在c-Met基因外显子14缺失的肺癌细胞系中,HLX55依然可以成功诱导目标蛋白降解,对于c-Met基因外显子14缺失突变引起的耐药群体,HLX55这个特征在...
Mesenchymal to epithelial transition (MET), the opposite of EMT, has been proposed as a mechanism for establishment of the metastatic neoplasm, leading to questions such as: Can MET be clearly demonstrated in vivo? What factors cause this phenotypic switch within the cancer cell? Are these ...
These histologic features connecting the secondary metastatic tumors to the primary is due to a process called mesenchymal-epithelial transition (MET). MET has been demonstrated in different mesenchymal tumors and is the expression of the reversibility of EMT. EMT modulation could constitute an approach...
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and
The epithelial–mesenchymal transition (EMT) process results in the downregulation of epithelial, and activation of mesenchymal, cell characteristics and behaviour. This transdifferentiation process is initially reversible, with mesenchymal–epithelial transition (MET) enabling reversion to an epithelial phenotype...
Mesenchymal to epithelial transition(MET), whereby mesenchymal cells become more epithelial like in phenotype,was observed to occur during normal development and in cancers. Numerous investigations have been conducted on MET in carcinomas. In addition, accumulating evidence also suggests the critical funct...
Mesenchymal-epithelial transition(MET) is a proto-oncogene that encodes for the transmembrane METTKI. The binding of its ligand, hepatocyte growth factor, activatessignaling pathwayssuch as PI3K/AKT,MAPK,nuclear factor kappa B, andsignal transducer and activator of transcription proteins, which promotes...
Epithelial-mesenchymal transition (EMT) is initially considered as a physiological phenomenon during the embryogenesis of mammals, as well as a basic biolo
The epithelial–mesenchymal transition (EMT) imparts properties of cancer stem-like cells, including resistance to frequently used chemotherapies, necessitating the identification of molecules that induce cell death specifically in stem-like cells with EMT properties. Herein, we demonstrate that breast can...