间质表皮转化因子 (c-Mesenchymal-epithelial transition factor, c-Met)是受体酪氨酸激酶的一种,较早就被发现在肿瘤细胞的活动中起到重要作用。这个蛋白对于肿瘤研究领域来说并不陌生,早在2008年,Nature Review Drug Discovery就发表过一篇关于c-Met抑制剂的详细综述[1]。这么多年,涉及c-Met靶点的项目并不在少数,...
Mesenchymal-epithelial transition(MET) is a proto-oncogene that encodes for the transmembrane METTKI. The binding of its ligand, hepatocyte growth factor, activatessignaling pathwayssuch as PI3K/AKT,MAPK,nuclear factor kappa B, andsignal transducer and activator of transcription proteins, which promotes...
Garg M. Epithelial-mesenchymal transition-activating transcrip- tion factors-multifunctional regulators in cancer. World J Stem Cells 2013; 5(4): 188-95.Minal Garg.Epithelial-mesenchymal transition-activating transcription factors-multifunctional regulators in cancer[J]. World Journal of Stem Cells.2013...
Mesenchymal epithelial transition factor receptor (Met) is a receptor tyrosine kinase that plays a critical role in promoting cancer cell malignant progression. Met is activated by its ligand hepatocyte growth factor (HGF). HGF-dependent Met activation p
上皮细胞间质转型（epithelial-mesenchymal transitions, EMT）是一种生物学过程，其中具有极性的上皮细胞转变为具有运动能力的间质细胞，同时获得侵袭和迁移的能力。这一过程对于人体的多个生理和病理状态至关重要。EMT的发生涉及到复杂的信号转导途径和多种分子机制。这些机制与钙连接素、生长因子、转录因子...
Mesenchymal to epithelial transition (MET), the opposite of EMT, has been proposed as a mechanism for establishment of the metastatic neoplasm, leading to questions such as: Can MET be clearly demonstrated in vivo? What factors cause this phenotypic switch within the cancer cell? Are these ...
生命科学领域中的一个重要现象是上皮细胞间质转型(EMT)，它是一种细胞生理过程，描述了极性的上皮细胞如何转变为具有迁移和侵袭能力的间质细胞。这一现象在人体的多种生理和病理环境中都发挥着关键作用，如胚胎发育、伤口愈合，甚至是肿瘤细胞的侵袭和转移中扮演着决定性角色。EMT的实现是一个涉及复杂信号...
Epithelial-Mesenchymal Transition 是指上皮细胞向间充质细胞转化的过程。EMT是一个复杂的生物学过程，在胚胎发育、组织修复以及疾病进展中扮演着重要角色。在这个过程中，上皮细胞逐渐失去其典型的极性、细胞间紧密连接等特性，并获得间充质细胞的特性，如增强迁移能力和对细胞外基质的交互作用。这一转化...
Epithelial-Mesenchymal Transition 是一种重要的生物学过程。EMT是指上皮细胞向间质细胞转变的过程。在此过程中，上皮细胞逐渐失去其典型的细胞连接和细胞极性，转变为具有迁移性和侵袭性的间质细胞表型。这种转变在胚胎发育、组织修复以及疾病进程中，如癌症的侵袭和转移中，发挥着关键作用。EMT过程涉及多个...
Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition Epithelial-mesenchymal transition (EMT) occurs during embryogenesis, carcinoma invasiveness, and metastasis and can be elicited by transforming growth fact... S Thuault,U Valcourt,M Petersen,... - 《Journal of ...