Because loss-of-function experiments in medaka and zebrafish had relied on morpholino, whose effect is transient and lasts only a few days post fertilization, developmental biology has been the major target of research using these small laboratory fish. With the advent of targeting-induced local ...
p53-deficienttumoursthroughupregulationofIAPP,thegenethat encodesamylin,a37-amino-acidpeptideco-secretedwithinsulinby thebcellsofthepancreas.WefoundthatIAPPiscausallyinvolved inthistumourregressionandthatamylinfunctionsthroughthe calcitoninreceptor(CalcR)andreceptoractivitymodifyingprotein3 ...
We validate CDC25A-NIP30-REGγ mediated regulation of the REGγ target protein p21 in vivo using p53/ and p53/REGγ double-deficient mice. Moreover, Phosphor-NIP30 mimetics significantly increase the growth inhibitory effect of chemotherapeutic agents in vitro and in vivo. Given that NIP30 is...
Further, inhibitors of poly(ADP-ribose) polymerase (PARPis) enhanced double-strand breaks (DSBs) and cell death in p53-deficient cells, and the combination of TAS102 with PARPi agents showed greater anti-tumor activity in p53Mut patient-derived xenograft (PDX) models than either drug alone, ...
PROLONGED SURVIVAL OF HEART ALLOGRAFTS FROM p53-DEFICIENT MICE1Background.Acute rejection of the heart allograft is the major cause of heart failure in the first month after transplantation. Most studies on the prevention of acute ... Hu,Yanhua,Zou,... - 《Transplantation》 被引量: 0发表: 20...
Retraction Note: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy Retraction of:Scientific Reportshttps://doi.org/10.1038/srep04694, published online 15 April 2014
Cisplatin could also induce typical apoptosis in p53-deficient baby mouse kidney (BMK) cells. The apoptosis was caspase dependent and could be completely blocked by general caspase inhibitors. Bax and Bak, two key molecules in the mitochondrial pathway of apoptosis, were interdependently activated by...
I am convening a meeting on behalf of the International Agency for Research on Cancer (IARC) to develop Vol. 119 of the IARC Monographs on 'Some Chemicals in Food and Consumer Products'. The agents…" [more]doi:10.1016/0378-4274(94)90397-2B. Rihn...
activating other targets, such as the p53 family member p73 and the caspase activator Apaf1. However, p53 activates the cyclin-dependent kinase inhibitor, p21Cip1, which can potentiate pRB-mediated repression of E2f1. Therefore, E2f1 also functions downstream of p53 for imposing cell-cycle arrest....
The p53-deficient mouse: a model for basic and applied cancer studies. Inactivation of the p53 gene in the germline of mice by gene targeting has provided researchers with a model similar in many respects to the analogous huma... LA Donehower - 《Seminars in Cancer Biology》...