Thus, in the p53-deficient mice, the hemopoietic stern cells after graded dose of radiation show a flatter survival curve for radiation, i.e., like a curve for radio-resistant phenotype. However, we found the radio-resistance in the stem cell was only transient, and an apoptosis in p53-...
Because loss-of-function experiments in medaka and zebrafish had relied on morpholino, whose effect is transient and lasts only a few days post fertilization, developmental biology has been the major target of research using these small laboratory fish. With the advent of targeting-induced local ...
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell. 2006;9:109-120.Haines BB, Ryu CJ, Chang S, Protopopov A, Luch A, Kang YH, et al. Block of T cell development in P53-deficient mice ...
thep53tumour suppressor gene are predisposed to tumours, but the viability of these animals indicates that p53 function is not essential for embryonic development. Here, we demonstrate that a fraction of p53–deficient embryos in fact do not develop normally. These animals display defects in neural...
In this study, p53-deficient cells (Hep3B and PC-3) and p53-expressing cells (A549 and HepG2) were treated with doxorubicin to examine the possible roles of TAp63 in these cells under genotoxic stress; TAp63 expression was induced in p53-deficient cell lines, but not in p53-expressing ...
PROLONGED SURVIVAL OF HEART ALLOGRAFTS FROM p53-DEFICIENT MICE1Background.Acute rejection of the heart allograft is the major cause of heart failure in the first month after transplantation. Most studies on the prevention of acute ... Hu,Yanhua,Zou,... - 《Transplantation》 被引量: 0发表: 20...
To examine whether autophagy is an important mechanism for 5-FU resistance in p53- deficient and mutant p53-expressing colon cancer cells, we compared HCT116 p531/1, HCT116 p532/2, RKO and HT-29 cell lines. Interestingly, the results suggested that functional autophagy was activated in HCT...
tumoursreprogrammingdeficientmetabolicregressioninduces LETTER doi:10.1038/nature13910 IAPP-drivenmetabolicreprogramminginduces regressionofp53-deficienttumoursinvivo AvinashnarayanVenkatanarayan 1,2,3,4 ,PayalRaulji 1,2 ,WilliamNorton 5 ,DeepavaliChakravarti 1,2,3,4 ,CristianCoarfa 6 , XiaohuaSu 1,2,4 ...
This was confirmed and amplified at a higher, lethal concentration, where undivided G2M-blocked p53-deficient cells eventually died by non-apoptotic mechanisms, while p53-proficient cells avoided this with a less stringent block. This gave p53-proficient cells more time to repair and eventually ...
Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta micedoi:10.1016/j.tox.2012.12.005ApoptosisKaryomegalyMutagenicityp53OchratoxinAOchratoxin A (OTA) is a mycotoxin produced by fungal species and is carcinogenic targeting the \\{S3\\} segment of the renal ...