来自美国冷泉港实验室,以色列魏茨曼科学研究所的研究人员发现了明星抑癌基因p53的一种非细胞自主抑癌作用的分子机制,具体来说,p53能通过调整抗肿瘤微环境而达到抑癌基因的作用。这一成果公布在Cell杂志上。 生物通报道:来自美国冷泉港实验室,以色列魏茨曼科学研究所的研究人员发现了明星抑癌基因p53的一种非细胞自主抑癌...
Human cells deficient in p53 regulated p21waf/cip1 expression exhibit normal nucleotide excision repair of UV-induced DNA damage. Carcinogenesis 2002;23(3) 403-410.Wani MA,Wani G,Yao J,et al.Human cell deficient in p53 regulated p21(waf1/cip1) expression exhibit normal muclectide excision ...
[3] Cheok, C. F. & Lane, D. P. Exploiting the p53 pathway for therapy. Cold SpringHarb. Perspect. Med. 7, a026310 (2017). [4] Mircetic J, Dietrich A, Paszkowski-Rogacz M, et al. Development of a genetic...
2n). Nevertheless, a significant increase in 13C-asparagine was found in p53-deficient cells (Fig. 2o). To verify the cell culture findings in animals, we compared the asparagine levels in tissues from p53+/+ mice and p53−/− mice. Consistent with the plasma data (Fig. 1c, ...
1993 Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5: 225–229 CAS PubMed Google Scholar Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT and Weinberg RA . 1994 Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4: 1–7...
Notably, MTHFD2 depletion strongly restrains p53-deficient cell proliferation and sensitizes cells to chemotherapeutic agents, indicating a potential role for MTHFD2 depletion in the treatment of p53-deficient tumors. 展开 关键词: MTHFD2 NHEJ cell proliferation folate metabolism p53 ...
Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is regulated by p53 via miR-34. p53 wild-type and p53-deficient cell lines (p53–/–and ...
近日,国内外泌体领域研究高产的钱晖、许文荣团队又出新成果,在国际知名干细胞领域杂志Stem Cells上发表题为“p53缺失的小鼠骨髓MSC外泌体富含UBR2通过Wnt/β-Catenin途径胃癌的进展”的文章,介绍了p53缺失的间充质干细胞分泌的外泌体富含一种蛋白UBR2,该蛋白可以以外泌体为载体转移到小鼠前胃癌细胞,从而促进胃癌的...
treated p53-deficient cells (Fig.3n). To dissect which p53 target genes are required for enhanced combined drug toxicity in OCI-AML3 cells, we used CRISPR/Cas9 to generate derivatives of OCI-AML3 cells lackingCDKN1A, BBC3andNOXA. Consistent with the observation that drug combination synergy is...
(Table 1). Recently, it was shown that p53-dependent regulation of enzymes is required for DNA methylation homeostasis.117In p53-deficient cells, an imbalance in DNA methylation causes clonal heterogeneity in naïve embryonal stem cells and upon differentiation. The DNA methyltransferase geneDNMT3B...