We show that pro-B lymphomas in mice deficient for both p53 and nonhomologous end-joining (NHEJ) contain complicons that coamplify c-myc (chromosome 15) and IgH (chromosome 12) sequences. While all carry a translocated (12;15) chromosome, coamplified sequences are located within a separate...
[3] Cheok, C. F. & Lane, D. P. Exploiting the p53 pathway for therapy. Cold SpringHarb. Perspect. Med. 7, a026310 (2017). [4] Mircetic J, Dietrich A, Paszkowski-Rogacz M, et al. Development of a genetic...
1993 Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5: 225–229 CAS PubMed Google Scholar Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT and Weinberg RA . 1994 Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4: 1–7...
Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. Wild-type (wt) p53 frequently induces apoptosis when expressed in tumor cells whereas mutant p53 acts as an oncoprotein and consequently, stimulates cell p... Stähler,Frauke,Roemer,....
E2f1 induces apoptosis in cultured cells through p53-dependent and -independent mechanisms. In the p53-dependent mechanism, E2f1 functions upstream of p53, inducing p19Arf, which stabilizes p53. In the p53-independent mechanism, E2f1 stimulates apoptosis by activating other targets, such as the p53 ...
In p53WT cells, the thymidine analog induced a transient activation of p53 and the DNA damage response, whereas p53-deficient cells responded with buildup of DNA damage and accumulation in G2/M phase. DNA damage induced by clinical thymidine analogs in p53-deficient cells We investigated further...
115 p53-deficient hepatic stellate cells, meanwhile, skew macrophages to a tumor-promoting M2 phenotype. Finally, p53 also induces DD1α to promote macrophage-mediated clearance of apoptotic cells, thereby limiting inflammation in the tumor microenvironment.116 p53 activation in the tumor stroma can ...
15. Skalniak L, Kocik J, Polak J, et al. Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells.Cancers (Basel).2018;10(11):396. Published 2018 Oct 24. doi:10.3390/cancers10110396 16. Kocik J, Machula M, Wisniewska A, Surmiak E, Holak TA, Skalniak...
al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient ...
2n). Nevertheless, a significant increase in 13C-asparagine was found in p53-deficient cells (Fig. 2o). To verify the cell culture findings in animals, we compared the asparagine levels in tissues from p53+/+ mice and p53−/− mice. Consistent with the plasma data (Fig. 1c, ...