Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for its prevention. The transcription factor p53 functions as a gatekeeper, regulating a myriad of genes to maintain normal cell ...
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Vousden KH, Lane DP (2007) p53 in health and disease. Nat Rev Mol Cell Biol 8(4):275–283 2. Brady CA, Attardi LD (2010) p53 at a glance. J Cell Sci 123(Pt 15):2527–2532 3. Sharpless NE, DePinho RA (2002) p53: good cop/bad cop. Cell 110(1):9–12 4. Aylon Y, ...
p53 in health and disease. Nat. Rev. 2007, 8, 275–283. [CrossRef] [PubMed] 2. Levine, A.J. p53, the cellular gatekeeper for growth and division. Cell 1997, 88, 323–331. [CrossRef] 3. Levine, A.J.; Oren, M. The first 30 years of p53: Growing ever more complex. Nat. ...
Nephrotoxicity is a major side-effect of cisplatin in chemotherapy, which can occur acutely or progress into chronic kidney disease (CKD). The protein p53 plays an important role in acute kidney injury induced by cisplatin, but its involvement in CKD following cisplatin exposure is unclear. Here,...
Finally, patients carrying TP53 mutations express lower LFNG than patients with wild type TP53. Taken together, these data revealed genetic interaction between Lfng and p53 in mammary tumorigenesis, established a new mouse model resembling CLBC, and may suggest targeting strategy for this disease....
and apoptosis-inducing factor (AIF), after binding to PAR polymer, released from mitochondria into nucleus to produce parthanatotic chromatinolysis [6]. Parthanatos has been proved to be involved in a lot of diseases including macular degeneration [7], parkinson's disease [8], smoke-related ...
In a large meta-analysis conducted in 1999, Grodstein et al. [3] found that hormone replacement therapy (HRT) use was associated with a decreased risk of colon cancer of approximately 35%. This association was further confirmed by the Women’s Health Initiative (WHI) Clinical Trial [4, 5...
p53 in health and disease. Nat Rev Mol Cell Biol 2007; 8: 275–283. 6 Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL et al. p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, ...