Luo XP. Phospholipase C epsilon-1 inhibits p53 expres- sion in lung cancer[ J]. Cell Biochem Funct, 2014, 32 (3) :294-298.Luo XP. Phospholipase C epsilon-1 inhibits p53 expression in lung cancer. Cell Biochem Funct. 2014;32:294-8....
近日,首都医科大学附属北京世纪坛医院石汉平教授、军事医学研究院孙强研究员和武汉大学中南医院周福祥教授合作在综合性期刊Advanced Science(IF=17.521)上在线发表了题为Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy ...
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4、 Schwartzenberg-Bar-Yoseph, F., Armoni, M., and Karnieli, E. (2004) The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression.Cancer Res. 64, 2627–2633 5、Kawauchi, K., Araki, K., Tobiume, K., and Tanaka, N. (2008) p53 regulates glucose me...
###Neat1 suppresses transformation in pancreatic cancer cells### 作者接下来试图在癌模型中检验Neat1的作用。作者特别关注胰腺导管腺癌(PDAC),这在小鼠中可以通过Pdx1-Cre介导的在胰腺中表达激活的Kras-G12D来模拟,因为作者发现在KrasG12D表达的前恶性胰腺上皮细胞中,Neat1的表达也是p53依赖的,这是在作者生成...
sensitivity through the down-regulation of XIAP expression in a p53 independent manner in hepatocellular carcinoma[J]. Biochem Biophys Res Commun, 2019, 508(3): 769-774. DOI: 10.1016/ j.bbrc.2018.11.181. [7] Lin M,...
Germ-line mutations in p53 occur in a high proportion of individuals with the Li–Fraumeni cancer susceptibility syndrome, which confers an increased risk of breast cancer [5]. This implies an important role for p53 inactivation in mammary carcinogenesis, and the structure and expression of p53 ha...
2013年,癌症基因组图谱(The Cancer Genome Atlas,TCGA)研究利用多组学分析提出子宫内膜癌分子分型,依据分子表型判断预后,分为4个亚型:POLE 超突变型(ultramutated)、MSI高突变型 (hypermutated)、Copy-number low (endometrioid)和Copy-number high (serous-like),其中POLE超突变型发生率约7%,预后最好;Copy-number ...
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previously, we identified maternal embryonic leucine z
3.1. p53 Expression in the Normal Tissue of Salivary Gland Surrounding the Pleomorphic Adenoma Three components, duct, acinar cells, and stroma were examined in the normal tissue adjacent to the pleomorphic adenoma Figure1. We evaluated the percentage of p53-positive cells in each case, with the...