2021年2月4日，来自美国纽约州立大学石溪分校的Luis A. Martinez团队在Cancer Cell杂志上在线发表题为“Mutant p53 suppresses innate immune signaling to promote tumorigenesis”的文章，报道了一种突变型p53通过抑制细胞自主和非自主信号以促进癌细胞存活和逃避肿瘤免疫监控的新机制，即突变型p53通过与TBK1相互作用抑制...
28、nal of cell biology, 2011, 192(2): 209-218.4. Feng Z, Hu W, De Stanchina E, et al. The regulation of AMPK 1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathwaysJ. Cancer rese...
(SV40) T antigen and adenovirus E1B oncoproteins.1–3 The p53 protein originally was believed to have an oncogenic rather than a tumor suppressor function, since it could immortalize cells in culture4 and cooperate with the activated ras oncogene to transform cells in culture.5'6 Overexpression ...
近日,来自新加坡癌症科学研究所的研究者们在Theranostics杂志上发表了题为“Role of p53 in breast cancer progression: An insight into p53 targeted therapy”的综述性文章,该研究强调了在临床前和临床开发中克服野生型和突变型携带p53的乳腺肿瘤中p53失活的治疗策略,并讨论了它们在临床前和临床环境中的有效性和局限...
[1] Hientz K, Mohr A, Bhakta-Guha D, Efferth T. The role of p53 in cancer drug resistance and targeted chemotherapy. Oncotarget. 2017;8(5):8921-8946. doi:10.18632/oncotarget.13475 [2] Steffen Boettcher et al. A dominant-negative effect drives selection of TP53 missense mutations in ...
[7].Ablasser A, Chen Z J. cGAS in action: Expanding roles in immunity and inflammation[J]. Science, 2019, 363(6431). [8].Bakhoum S F, Cantley L C. The multifaceted role of chromosomal instability in cancer and its microenvironment[J]. Cell, 2018, 174(6): 1347-1360. ...
Mutp53 has gain-of-function that plays a key role in promoting malignant phenotype of cancer, and what is the mechanism of its generation of gain-of-function phenotype? Can mutp53 be used as prognostic marker for tumors to make more accurate diagnosis, and monitor the response to treatment ...
A protein called p53 plays a key role in the body's immune response to cancer, and therefore ...
and cancer. The tumor repressor p53 plays a key role in DNA damage response, and has been found to be mutated in 50% of human cancer. p53, p63, and p73 are three members of the p53 gene family. Recent discoveries have shown that human p53 gene encodes at least 12 isoforms. Different...
[7].Ablasser A, Chen Z J. cGAS in action: Expanding roles in immunity and inflammation[J]. Science, 2019, 363(6431). [8].Bakhoum S F, Cantley L C. The multifaceted role of chromosomal instability in cancer and its microenvironment[J]. Cell, 2018, 174(6): 1347-1360. ...