P53 Expression in Node-Positive Breast Cancer Patients Receiving Docetaxel-Based Adjuvant ChemotherapyInflammatory breast cancer (IBC) is one of the most aggressive subtypes of breast cancer. IBC represents 24 of breast cancer, but it represents 10 of breast cancer-related mortality. Despite ...
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previously, we identified maternal embryonic leucine z
Barbareschi M, Caffo O, Veronese S, Leek RD, Fina P, Fox S, Bonzanini M, Girlando S, Morelli L, Eccher C, Pezzella F, Doglioni C, Dalla Palma P and Harris A (1996) Bcl-2 and p53 expression in node-negative breast carcinoma: a study with long-term follow-up. Hum Pathol 27...
Fig. 1: PLD3 functioned as a tumor suppressor gene in breast cancer. A PLD3 expression in stable PLD3-overexpression cells (231-PLD3) and control cells (231-Vector) was determined by the western blot. MTT (B) and colony-formation (C) analyzed the proliferation of the cells described in...
Ectopic expression of TIP30/CC3 was found to elevate the expression of a subset of proapoptotic genes and angiogenic inhibitors and to down-regulate the expression of certain angiogenic stimulators [6], [7]. The role of TIP30/CC3 in breast cancer has not been fully identified. Recently, ...
Molecular pathological analysis of the structure and expression of constituents of the p53 pathway is likely to have value in diagnosis, in prognostic assessment and, ultimately, in treatment of breast cancer.Introduction First described in 1979, and initially believed to be an oncogene, p53 was ...
Mutant p53 and ELK1 co-drive FRA-1 expression to induce metastasis in breast cancer 来自 科研支点 喜欢 0 阅读量: 7 作者: S Hu,M Wang,Ji A.Yang J.Gao R.Li X.Sun L.Wang J.Zhang Y.Liu H. 摘要: Tumor-associated p53 mutations induce activities different from wild-type p53, thus ...
p53 and C-erbB-2 had no statistically significant in different age,tumor size,tumor stage and groups with or without lymph node metastasis.Conclusions Over expressions of ER,PR,p53 and C-erbB-2 are found in breast cancer tissue,the expression of ER correlates with tumor size and metastasis ...
Interestingly, mutant p53 ablation attenuates the activity of NF-κ B and renders cancer cells susceptible to killing by TNF. Finally, we observed a close correlation between the high frequency of p53 mutations and the elevated expression of NF-κ B target genes in breast tumors. Therefore, our...
operationandthesamplesof21patientswithbreastcancerwereanalyzedbyimmunocytochemistryandcomputerimaging technique.Results Theexpressionlevelofbcl一2proteininhumanbreastcancer(52. 4%,11/21)wassignificantlyhigher thanthatinnormalbreasttissues(19. 0%,4/21).Theexpressionlevelofp53proteininbreastcancer(57.1%,12/21) ...