Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molec- ular determinants of human cancer malignancy. Molecular cancer. 2010; 9:193.García-Escudero R, Martínez-Cruz AB, Santos M et al (2010) Gene expression profiling of mouse p53-deficient epidermal carcinoma defines ...
2. DeLeo AB, Jay G, Appella E, Dubois GC, Law LW, Old LJ. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.Proc Natl Acad Sci U S A. 1979;76(5):2420-2424. doi:10.1073/pnas.76.5.2420 3. Lane D, Levine A. p53 ...
2n). Nevertheless, a significant increase in 13C-asparagine was found in p53-deficient cells (Fig. 2o). To verify the cell culture findings in animals, we compared the asparagine levels in tissues from p53+/+ mice and p53−/− mice. Consistent with the plasma data (Fig. 1c, ...
p53 K117R mutant knock-in mice, which completely abolished p53-mediated apoptosis [8]. In comparison to p53-deficient or p53 wild-type tumors, tumors carrying mutp53 exhibit more aggressive and metastatic properties [9,10,11]. GermlineTP53mutations are the cause of Li-Fraumeni syndrome, which ...
al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient ...
RB1-deficient retinal cells. Our data provide evidence that the p53 pathway is inactivated in retinoblastoma and that this cancer does not originate from intrinsically death-resistant cells as previously thought. In addition, they support the
al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient ...
Survival Of Mhc-Deficient Mouse Heterotopic Cardiac Allografts The immunologic mechanisms involved in the destruction of murine cardiac allografts were evaluated using MHC-deficient mice. Specifically, we examined the ... L Campos,A Naji,BC Deli,... - 《Transplantation Journal》 被引量: 0发表: 199...
Mutant p53 induced PDGFRb through a cell-autonomous mechanism involving inhibition of a p73/NF-Y complex that represses PDGFRb expression in p53-deficient, noninvasive cells. Blocking PDGFRb signaling by RNA interference or by small molecule inhibitors prevented pancreatic cancer cell invasion in vitro ...
MDM2,MDMXandp53isactivatedafterlossofRB1duringretinogenesis.RB1-deficientretinoblastsundergop53mediatedapoptosisandexitthecellcycle.Subsequently,amplificationoftheMDMXgeneandincreasedexpressionofMDMXproteinarestronglyselectedforduringtumourprogressionasamechanismtosuppressthep53responseinRB1deficientretinalcells.Ourdata...